cis-1-(bromomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran

Base Information

Chemical Name:cis-1-(bromomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran
CAS No.:134456-08-9
Molecular Formula:C₂₂H₂₉BrO₃
Molecular Weight:421.374
Hs Code.:

Synonyms:cis-1-(bromomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran

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Chemical Property of cis-1-(bromomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran

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Technology Process of cis-1-(bromomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran

There total 3 articles about cis-1-(bromomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 7252-83-7
1-bromo-2,2-dimethoxyethane

: 134456-07-8
2-cyclohexyl-1-spiro<1,3-benzodioxole-2,1'-cyclohexane>-2-ethanol

: 134456-08-9
cis-1-(bromomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran

Guidance literature:: With boron trifluoride diethyl etherate; In diethyl ether; for 24h; Ambient temperature;
DOI:10.1021/jm00112a034

Reference yield:

: 3483-39-4
Cyclohexyloxirane

: 134456-08-9
cis-1-(bromomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) hexane, THF, RT, 4 h, 2.) hexane, THF, from 0 deg C to RT, 2 h

2: 77 percent / BF₃OEt₂ / diethyl ether / 24 h / Ambient temperature

With n-butyllithium; boron trifluoride diethyl etherate; In diethyl ether;
DOI:10.1021/jm00112a034

Reference yield:

: 182-55-8
spiro[benzo[d][1,3]dioxole-2,1'-cyclohexane]

: 134456-08-9
cis-1-(bromomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) hexane, THF, RT, 4 h, 2.) hexane, THF, from 0 deg C to RT, 2 h

2: 77 percent / BF₃OEt₂ / diethyl ether / 24 h / Ambient temperature

With n-butyllithium; boron trifluoride diethyl etherate; In diethyl ether;
DOI:10.1021/jm00112a034