N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine

Base Information

Chemical Name:N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine
CAS No.:1350645-14-5
Molecular Formula:C₁₇H₁₁ClFN₅
Molecular Weight:339.759
Hs Code.:

Synonyms:N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine

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Chemical Property of N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine

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Technology Process of N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine

There total 6 articles about N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.5%

: 1350648-20-2
7-iodo-1H-pyrazolo[4,3-b]pyridine

: 1350648-22-4
2-(5-chloro-2-fluorophenyl)pyridin-4-amine

: 1350645-14-5
N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine

Guidance literature:: 7-iodo-1H-pyrazolo[4,3-b]pyridine; With sodium hydride; In N,N-dimethyl-formamide; for 0.166667h;

With p-methoxybenzyl chloride; In N,N-dimethyl-formamide; for 0.5h; Cooling with ice;

2-(5-chloro-2-fluorophenyl)pyridin-4-amine; With sodium t-butanolate; palladium diacetate; at 100 ℃; Product distribution / selectivity;

Reference yield:

: 352535-83-2
5-chloro-2-fluorophenylboronic acid

: 1350645-14-5
N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 3 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

2.2: 0.5 h / Cooling with ice

2.3: 100 °C

With sodium hydride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 14432-12-3
4-Amino-2-chloropyridine

: 1350645-14-5
N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 3 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

2.2: 0.5 h / Cooling with ice

2.3: 100 °C

With sodium hydride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; N,N-dimethyl-formamide;