1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)-N-isoxazol-3-ylpiperidine-4-carboxamide trifluoroacetate

Base Information

Chemical Name:1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)-N-isoxazol-3-ylpiperidine-4-carboxamide trifluoroacetate
CAS No.:960390-76-5
Molecular Formula:C₂HF₃O₂*C₂₈H₃₅F₂N₅O₃
Molecular Weight:641.638
Hs Code.:

1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)-N-isoxazol-3-ylpiperidine-4-carboxamide trifluoroacetate

Synonyms:1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)-N-isoxazol-3-ylpiperidine-4-carboxamide trifluoroacetate

Suppliers and Price of 1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)-N-isoxazol-3-ylpiperidine-4-carboxamide trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)-N-isoxazol-3-ylpiperidine-4-carboxamide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)-N-isoxazol-3-ylpiperidine-4-carboxamide trifluoroacetate

There total 11 articles about 1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)-N-isoxazol-3-ylpiperidine-4-carboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1750-42-1
3-aminoisoxazole

: C₂₅H₃₂ClF₂N₃O₂

: 960390-76-5
1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)-N-isoxazol-3-ylpiperidine-4-carboxamide trifluoroacetate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 960391-21-3
2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-carboxylic acid

: 960390-76-5
1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)-N-isoxazol-3-ylpiperidine-4-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

2.1: lithium hydroxide; water / 1,4-dioxane / 2 h / 75 °C

2.2: pH 5 - 6

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 20 °C

4.1: triethylamine / dichloromethane / 2 h / 20 °C

With lithium hydroxide; oxalyl dichloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 809273-67-4
methyl 3-amino-4-{[(4,4-difluorocyclohexyl)methyl]amino}benzoate

: 960390-76-5
1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)-N-isoxazol-3-ylpiperidine-4-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap / dichloromethane / 4 h / 20 °C

2.1: acetic acid / 3 h / 150 °C / Microwave irradiation

3.1: lithium hydroxide; water / 1,4-dioxane / 3 h / 75 °C

3.2: pH 5 - 6

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

5.1: lithium hydroxide; water / 1,4-dioxane / 2 h / 75 °C

5.2: pH 5 - 6

6.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 20 °C

7.1: triethylamine / dichloromethane / 2 h / 20 °C

With dmap; lithium hydroxide; oxalyl dichloride; water; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;