23-O-acetylsilybin B

Base Information

• Chemical Name: 23-O-acetylsilybin B
• CAS No.: 1220986-70-8
• Molecular Formula: C₂₇H₂₄O₁₁
• Molecular Weight: 524.481
• Mol file: 1220986-70-8.mol

Synonyms:23-O-acetylsilybin B

Chemical Property of 23-O-acetylsilybin B

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 23-O-acetylsilybin B

There total 4 articles about 23-O-acetylsilybin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

acetic anhydride (108-24-7) + silybin B (22888-70-6) → 23-O-acetylsilybin B (1220986-70-8)

Guidance literature:

With boron trifluoride diethyl etherate; In tetrahydrofuran; diethyl ether; at 0 ℃; for 1h; optical yield given as %de;

DOI:10.1021/np900758d

Reference yield: 30.0%

23-O-acetylsilibinin (871249-25-1) → 23-O-acetylsilybin A (1220986-69-5) + 23-O-acetylsilybin B (1220986-70-8) + silybin B (22888-70-6)

Guidance literature:

With Candida antarctica lipase B; butan-1-ol; In toluene; at 45 ℃; for 48h; optical yield given as %de; diastereoselective reaction;

DOI:10.1021/np900758d

Reference yield: 17.0%

vinyl acetate (108-05-4,9003-20-7) + silybin B (22888-70-6) → 23-O-acetylsilybin B (1220986-70-8) + (2R,3S,10S,11S)-23-O-acetylsilybin

Guidance literature:

silybin B; With boron trifluoride diethyl etherate; In diethyl ether; N,N-dimethyl-formamide; at 50 ℃; for 1h;

vinyl acetate; In acetone; at 45 ℃; for 48h; Enzymatic reaction;

DOI:10.3762/bjoc.10.105

upstream raw materials:

vinyl acetate

silybin

23-O-acetylsilibinin

acetic anhydride

Downstream raw materials:

silybin B

Refernces

• 1、 Monti, Daniela,Gazak, Radek,Marhol, Petr,Biedermann, David,Purchartova, Katerina,Fedrigo, Mirko,Riva, Sergio,Kren, Vladimir. "Enzymatic kinetic resolution of silybin diastereoisomers". scheme or table. p. 613 - 619. Retrieved 2010/07/13.