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Silibinin

Base Information Edit
  • Chemical Name:Silibinin
  • CAS No.:22888-70-6
  • Deprecated CAS:11054-49-2,11076-05-4,11076-06-5,22888-69-3,50976-99-3,37574-50-8,142796-20-1,87725-90-4,27359-03-1,28577-40-4,29832-10-8,11076-05-4,11076-06-5,142796-20-1,22888-69-3,27359-03-1,29832-10-8,37574-50-8,50976-99-3,87725-90-4
  • Molecular Formula:C25H22O10
  • Molecular Weight:482.444
  • Hs Code.:29329990
  • European Community (EC) Number:245-302-5,613-830-9,678-483-8,806-403-5
  • NSC Number:651520
  • UNII:33X338MNE4
  • DSSTox Substance ID:DTXSID8026018
  • Nikkaji Number:J11.473A
  • Wikipedia:Silibinin
  • Wikidata:Q425702
  • NCI Thesaurus Code:C152359,C26671
  • Metabolomics Workbench ID:53434
  • ChEMBL ID:CHEMBL431701
  • Mol file:22888-70-6.mol
Silibinin

Synonyms:2,3 Dehydrosilybin;2,3-dehydrosilybin;Alepa forte;Alepa-forte;Ardeyhepan;Cefasilymarin;durasilymarin;Hepa loges;Hepa Merz Sil;hepa-loges;Hepa-Merz Sil;HepaBesch;Hepar Pasc;Hepar-Pasc;Heparsyx;Heplant;Lagosa;legalon forte;silibin;silibinin;Silibinin A;Silibinin B;silybin;silybin A;silybin B;silybinin

Suppliers and Price of Silibinin
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Silybin
  • 20mg
  • $ 263.00
  • TRC
  • SilybinA
  • 1mg
  • $ 145.00
  • Sigma-Aldrich
  • Silibinin ≥98% (HPLC)
  • 1g
  • $ 42.00
  • Sigma-Aldrich
  • Silybin Pharmaceutical Secondary Standard; Certified Reference Material
  • 100MG
  • $ 129.00
  • Sigma-Aldrich
  • Silibinin ≥98% (HPLC)
  • 10g
  • $ 125.00
  • Sigma-Aldrich
  • Silybin United States Pharmacopeia (USP) Reference Standard
  • 50mg
  • $ 325.00
  • Sigma-Aldrich
  • Silybin mixture of Silybin A and B, primary reference standard
  • 25 mg
  • $ 654.00
  • JR MediChem
  • Silibinin 98%
  • 25g
  • $ 918.00
  • JR MediChem
  • Silibinin 98%
  • 5g
  • $ 368.00
  • DC Chemicals
  • Silibinin >98%,StandardReferencesGrade
  • 20 mg
  • $ 280.00
Total 236 raw suppliers
Chemical Property of Silibinin Edit
Chemical Property:
  • Appearance/Colour:solid 
  • Vapor Pressure:1.63E-26mmHg at 25°C 
  • Melting Point:164-174 °C 
  • Refractive Index:1.684 
  • Boiling Point:793 °C at 760 mmHg 
  • PKA:pKa 6.42±0.04 (Uncertain) 
  • Flash Point:274.5 °C 
  • PSA:155.14000 
  • Density:1.527 g/cm3 
  • LogP:2.36270 
  • Storage Temp.:−20°C 
  • Solubility.:Acetone (Sparingly), DMSO, Methano (Sparingly) 
  • Water Solubility.:54mg/L(24.99 oC) 
  • XLogP3:2.4
  • Hydrogen Bond Donor Count:5
  • Hydrogen Bond Acceptor Count:10
  • Rotatable Bond Count:4
  • Exact Mass:482.12129689
  • Heavy Atom Count:35
  • Complexity:750
Purity/Quality:

24%, *data from raw suppliers

Silybin *data from reagent suppliers

Safty Information:
  • Pictogram(s): IrritantXi 
  • Hazard Codes:Xi 
  • Statements: 36/37/38 
  • Safety Statements: 26-37/39-24/25-22-36 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O
  • Isomeric SMILES:COC1=C(C=CC(=C1)[C@@H]2[C@H](OC3=C(O2)C=C(C=C3)[C@@H]4[C@H](C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O
  • Recent ClinicalTrials:SILibinin in NSCLC and BC Patients With Single Brain METastasis (SILMET)
  • Recent EU Clinical Trials:Efficacy and safety of Silycus? in Cushing’s disease: a multicenter, single arm, open
  • Uses Silibinin has been used:to study its effect on gene expression levels of various proteins involved in chromatin regulations of prostate cancer, by real time polymerase chain reaction (RT-PCR)to study its effect on cell proliferation in platelet-derived growth factor (PDGF)-treated human tenon′s fibroblasts (HTFs) by investigating the expression of proliferating cell nuclear antigen (PCNA) and by water-soluble tetrazolium salt (WST-1) assayto examine its effect on gene expression levels of stromelysine 1 (STM1), acetyl hexoseamines and collagen production during skin wound healingto study its inhibitory effect on Escherichia coli ATP synthase Labelled Silybin (S465850). Hepatoprotectant.
  • Therapeutic Function Hepatoprotectant
Technology Process of Silibinin

There total 22 articles about Silibinin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With Candida antarctica lipase B; butan-1-ol; In tert-butyl methyl ether; at 45 ℃; for 60h; optical yield given as %de; diastereoselective reaction;
DOI:10.1021/np900758d
Guidance literature:
With Candida antarctica lipase B; butan-1-ol; In toluene; at 45 ℃; for 48h; optical yield given as %de; diastereoselective reaction;
DOI:10.1021/np900758d
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