(2S,5R,1'R)-2-[2'-(diethoxyphosphoryl)-1'-phenylethyl]-3,6-diethoxy-2,5-dihydro-5-isopropyl-2-methylpyrazine

Base Information

Chemical Name:(2S,5R,1'R)-2-[2'-(diethoxyphosphoryl)-1'-phenylethyl]-3,6-diethoxy-2,5-dihydro-5-isopropyl-2-methylpyrazine
CAS No.:261167-62-8
Molecular Formula:C₂₄H₃₉N₂O₅P
Molecular Weight:466.558
Hs Code.:

Synonyms:(2S,5R,1'R)-2-[2'-(diethoxyphosphoryl)-1'-phenylethyl]-3,6-diethoxy-2,5-dihydro-5-isopropyl-2-methylpyrazine

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Chemical Property of (2S,5R,1'R)-2-[2'-(diethoxyphosphoryl)-1'-phenylethyl]-3,6-diethoxy-2,5-dihydro-5-isopropyl-2-methylpyrazine

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Technology Process of (2S,5R,1'R)-2-[2'-(diethoxyphosphoryl)-1'-phenylethyl]-3,6-diethoxy-2,5-dihydro-5-isopropyl-2-methylpyrazine

There total 7 articles about (2S,5R,1'R)-2-[2'-(diethoxyphosphoryl)-1'-phenylethyl]-3,6-diethoxy-2,5-dihydro-5-isopropyl-2-methylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25362-01-0
(Z)-diethyl styrylphosphonate

: (R)-3,6-Diethoxy-2-isopropyl-5-methyl-2,5-dihydro-pyrazine

: 261167-62-8
(2S,5R,1'R)-2-[2'-(diethoxyphosphoryl)-1'-phenylethyl]-3,6-diethoxy-2,5-dihydro-5-isopropyl-2-methylpyrazine

: 261167-63-9
(2S,5R,1'S)-2-[2'-(diethoxyphosphoryl)-1'-phenylethyl]-3,6-diethoxy-2,5-dihydro-5-isopropyl-2-methylpyrazine

Guidance literature:: (R)-3,6-Diethoxy-2-isopropyl-5-methyl-2,5-dihydro-pyrazine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

(Z)-diethyl styrylphosphonate; In tetrahydrofuran; hexane; at -78 ℃;
DOI:10.1021/jo034707q

Reference yield:

: 20408-33-7
diethyl (E)-(2-phenylethenyl)phosphonate

: (R)-3,6-Diethoxy-2-isopropyl-5-methyl-2,5-dihydro-pyrazine

: 261167-62-8
(2S,5R,1'R)-2-[2'-(diethoxyphosphoryl)-1'-phenylethyl]-3,6-diethoxy-2,5-dihydro-5-isopropyl-2-methylpyrazine

: 261167-63-9
(2S,5R,1'S)-2-[2'-(diethoxyphosphoryl)-1'-phenylethyl]-3,6-diethoxy-2,5-dihydro-5-isopropyl-2-methylpyrazine

Guidance literature:: (R)-3,6-Diethoxy-2-isopropyl-5-methyl-2,5-dihydro-pyrazine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

diethyl (E)-(2-phenylethenyl)phosphonate; In tetrahydrofuran; hexane; at -78 ℃;
DOI:10.1021/jo034707q

Reference yield:

: 683-08-9
Diethyl methylphosphonate

: 261167-62-8
(2S,5R,1'R)-2-[2'-(diethoxyphosphoryl)-1'-phenylethyl]-3,6-diethoxy-2,5-dihydro-5-isopropyl-2-methylpyrazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA; (EtO)2P(O)Cl / tetrahydrofuran

1.2: tetrahydrofuran

2.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: tetrahydrofuran; hexane / -78 °C

With n-butyllithium; diethyl chlorophosphate; lithium diisopropyl amide; In tetrahydrofuran; hexane; 1.2: Wadsworth-Emmons olefination;
DOI:10.1021/jo034707q