2-Hydroxy-1-(4-(2-hydroxyethoxy)phenyl)-2-methylpropan-1-one

Base Information

• Chemical Name: 2-Hydroxy-1-(4-(2-hydroxyethoxy)phenyl)-2-methylpropan-1-one
• CAS No.: 106797-53-9
• Deprecated CAS: 1245745-22-5,1269810-51-6,1332635-02-5,165895-50-1,2253104-00-4,2569208-16-6,1269810-51-6
• Molecular Formula: C12H16O4
• Molecular Weight: 224.257
• Hs Code.: 29145090
• European Community (EC) Number: 402-670-3,600-777-1
• DSSTox Substance ID: DTXSID6044777
• Nikkaji Number: J640.171F
• Wikidata: Q72484385
• ChEMBL ID: CHEMBL3188617
• Mol file: 106797-53-9.mol

Synonyms:2-hydroxy-1-(4-(hydroxyethoxy)phenyl)-2-methyl-1-propanone;Irgacure 2959

Chemical Property of 2-Hydroxy-1-(4-(2-hydroxyethoxy)phenyl)-2-methylpropan-1-one

Chemical Property:

• Vapor Pressure: 0Pa at 25℃
• Melting Point: 88-90 °C(lit.)
• Boiling Point: 405 °C at 760 mmHg
• PKA: 12.96±0.29(Predicted)
• Flash Point: 155.8 °C
• PSA: 66.76000
• Density: 1.183 g/cm³
• LogP: 1.01130
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• Water Solubility.: 7.6g/L at 25℃
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 224.10485899
• Heavy Atom Count: 16
• Complexity: 229

Purity/Quality:

99%min ^*data from raw suppliers

2-Hydroxy-4''-(2-hydroxyethoxy)-2-methylpropiophenone ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C(=O)C1=CC=C(C=C1)OCCO)O
• Description: 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone(Photoinitiator 2959) has been tested for use in UV curing formulations on wood, metal, plastic and paper surfaces.It has lower volatility and odor compared to Irgacure 1173. Importantly, the reactive hydroxyl groups of it are easily grafted onto the polymer molecules, making it more convenient to process.
• Uses: 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone is a photoinitiator allowed by the FDA certification system; it can be used in water-based photocuring systems, with high melting point, and can also be used in UV-curable powder coatings; it is a high-efficiency non-yellowing UV photoinitiator. UV polymerization of saturated prepolymerized systems.

Technology Process of 2-Hydroxy-1-(4-(2-hydroxyethoxy)phenyl)-2-methylpropan-1-one

There total 4 articles about 2-Hydroxy-1-(4-(2-hydroxyethoxy)phenyl)-2-methylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-(4-(2-hydroxyethoxy)phenyl)-2-methylpropan-1-one (159119-01-4) → (2-hydroxy-1-[4-(2-hydroxyethoxy)phenyl]-2-methyl-1-propanone) (106797-53-9)

Guidance literature:

With N-Bromosuccinimide; dimethyl sulfoxide; at 100 ℃; for 24h;

DOI:10.1021/ol5037387

Reference yield: 78.0%

4-hydroxyethyltrichloromethylbenzene + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → (2-hydroxy-1-[4-(2-hydroxyethoxy)phenyl]-2-methyl-1-propanone) (106797-53-9)

Guidance literature:

With magnesium; In N,N-dimethyl-formamide; at -20 - -10 ℃; for 2h; Inert atmosphere;

Reference yield:

4-(2-acetoxyethoxy)-phenyl 2-propyl ketone (106797-52-8) → (2-hydroxy-1-[4-(2-hydroxyethoxy)phenyl]-2-methyl-1-propanone) (106797-53-9)

Guidance literature:

With sodium hydroxide; bromine; In ice-water; ethanol; acetic acid; ethyl acetate;

upstream raw materials:

4-(2-acetoxyethoxy)-phenyl 2-propyl ketone

1-(4-(2-hydroxyethoxy)phenyl)-2-methylpropan-1-one

2-phenoxyethyl acetate

cyclohexanone

Downstream raw materials:

2-Hydroxy-2-methyl-1-[4-(2-oxiranylmethoxyethoxy)phenyl]propan-1-one

C₁₆H₂₀O₆

C₁₆H₂₀O₆

tert-butyl alcohol

Refernces

Cationic hybrid hydrogels from amino-acid-based poly(ester amide): Fabrication, characterization, and biological properties

10.1002/adfm.201103147

The research focuses on the development of a new family of cationic charged biocompatible hybrid hydrogels, based on arginine unsaturated poly(ester amide) (Arg-UPEA) and Pluronic diacrylate (Pluronic-DA), which were fabricated through UV photocrosslinking in an aqueous medium. The purpose of this study was to improve the cellular interactions of synthetic hydrogels for potential biomedical applications by introducing cationic Arg-UPEA, which possesses biocompatibility and cationic properties. The conclusions drawn from the research indicate that the incorporation of Arg-UPEA into Pluronic-DA hydrogels significantly enhanced cell attachment, proliferation, and viability of both Detroit 539 human fibroblasts and bovine aortic endothelial cells. The chemicals used in the process include Pluronic F127, acryloyl chloride, triethylamine, Irgacure 2959 (as a photoinitiator), L-arginine, p-toluenesulfonic acid monohydrate, fumaryl chloride, ethylene glycol, 1,3-propanediol, 1,4-butanediol, 1,6-hexanediol, and p-nitrophenol, among others. These chemicals were utilized in the synthesis of the hydrogel precursors and for the characterization of their physicochemical properties.