Technology Process of 1-benzyl 8-methyl 3-(2-ethylhexyl)octanedioate
There total 3 articles about 1-benzyl 8-methyl 3-(2-ethylhexyl)octanedioate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2-ethylhexyl)lithium;
With
copper(I) bromide dimethylsulfide complex;
In
tetrahydrofuran; n-heptane;
at -15 ℃;
for 0.333333h;
(E/Z)-1-benzyl 8-methyl oct-2-enedioate;
With
chloro-trimethyl-silane;
In
tetrahydrofuran; n-heptane;
at -78 ℃;
for 3h;
DOI:10.1016/j.bmcl.2012.09.093
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sulfuric acid / water / 0.33 h / pH 6
2.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.75 h / -78 °C
2.2: 1 h / -78 - 20 °C
3.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
3.2: 1.25 h / -78 - 20 °C / Inert atmosphere
4.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran; n-heptane / 0.33 h / -15 °C
4.2: 3 h / -78 °C
With
oxalyl dichloride; copper(I) bromide dimethylsulfide complex; sulfuric acid; sodium hydride; dimethyl sulfoxide;
In
tetrahydrofuran; n-heptane; dichloromethane; water;
2.1: |Swern Oxidation / 2.2: |Swern Oxidation / 3.1: |Horner-Wadsworth-Emmons Olefination / 3.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.bmcl.2012.09.093
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
1.2: 1.25 h / -78 - 20 °C / Inert atmosphere
2.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran; n-heptane / 0.33 h / -15 °C
2.2: 3 h / -78 °C
With
copper(I) bromide dimethylsulfide complex; sodium hydride;
In
tetrahydrofuran; n-heptane;
1.1: |Horner-Wadsworth-Emmons Olefination / 1.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.bmcl.2012.09.093
