1-benzyl 8-methyl 3-(2-ethylhexyl)octanedioate

Base Information

Chemical Name:1-benzyl 8-methyl 3-(2-ethylhexyl)octanedioate
CAS No.:1411986-14-5
Molecular Formula:C₂₄H₃₈O₄
Molecular Weight:390.563
Hs Code.:

Synonyms:1-benzyl 8-methyl 3-(2-ethylhexyl)octanedioate

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Chemical Property of 1-benzyl 8-methyl 3-(2-ethylhexyl)octanedioate

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Technology Process of 1-benzyl 8-methyl 3-(2-ethylhexyl)octanedioate

There total 3 articles about 1-benzyl 8-methyl 3-(2-ethylhexyl)octanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: (E/Z)-1-benzyl 8-methyl oct-2-enedioate

: 13067-81-7
(2-ethylhexyl)lithium

: 1411986-14-5
1-benzyl 8-methyl 3-(2-ethylhexyl)octanedioate

Guidance literature:: (2-ethylhexyl)lithium; With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; n-heptane; at -15 ℃; for 0.333333h;

(E/Z)-1-benzyl 8-methyl oct-2-enedioate; With chloro-trimethyl-silane; In tetrahydrofuran; n-heptane; at -78 ℃; for 3h;
DOI:10.1016/j.bmcl.2012.09.093

Reference yield:

: 502-44-3,24980-41-4,80137-66-2
hexahydro-2H-oxepin-2-one

: 1411986-14-5
1-benzyl 8-methyl 3-(2-ethylhexyl)octanedioate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / water / 0.33 h / pH 6

2.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.75 h / -78 °C

2.2: 1 h / -78 - 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

3.2: 1.25 h / -78 - 20 °C / Inert atmosphere

4.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran; n-heptane / 0.33 h / -15 °C

4.2: 3 h / -78 °C

With oxalyl dichloride; copper(I) bromide dimethylsulfide complex; sulfuric acid; sodium hydride; dimethyl sulfoxide; In tetrahydrofuran; n-heptane; dichloromethane; water; 2.1: |Swern Oxidation / 2.2: |Swern Oxidation / 3.1: |Horner-Wadsworth-Emmons Olefination / 3.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.bmcl.2012.09.093

Reference yield:

: 6654-36-0
methyl 6-oxohexanoate

: 1411986-14-5
1-benzyl 8-methyl 3-(2-ethylhexyl)octanedioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

1.2: 1.25 h / -78 - 20 °C / Inert atmosphere

2.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran; n-heptane / 0.33 h / -15 °C

2.2: 3 h / -78 °C

With copper(I) bromide dimethylsulfide complex; sodium hydride; In tetrahydrofuran; n-heptane; 1.1: |Horner-Wadsworth-Emmons Olefination / 1.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.bmcl.2012.09.093