4-[(2,3-dihydro-1-imino-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

Base Information

Chemical Name:4-[(2,3-dihydro-1-imino-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol
CAS No.:1264924-47-1
Molecular Formula:C₁₉H₁₇N₅O
Molecular Weight:331.377
Hs Code.:

Synonyms:4-[(2,3-dihydro-1-imino-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

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Chemical Property of 4-[(2,3-dihydro-1-imino-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

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Technology Process of 4-[(2,3-dihydro-1-imino-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

There total 5 articles about 4-[(2,3-dihydro-1-imino-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89001-53-6
2-cyano-5-nitrotoluene

: 1264924-47-1
4-[(2,3-dihydro-1-imino-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

: 1264924-50-6
2,3-dihydro-1-imino-N-[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]-1H-isoindol-5-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 72 h / Reflux; Inert atmosphere

2: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 20 °C

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran

4: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 110 °C / sealed tube; Inert atmosphere

5: tetra-(n-butyl)ammonium iodide; hydrogen iodide / water / 0.5 h / 100 °C / microwave reactor

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydrogen iodide; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; tetrachloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1264926-49-9
C₃₀H₃₅N₅O₅

: 1264924-47-1
4-[(2,3-dihydro-1-imino-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

: 1264924-50-6
2,3-dihydro-1-imino-N-[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]-1H-isoindol-5-amine

Guidance literature:: With hydrogen iodide; tetra-(n-butyl)ammonium iodide; In water; at 100 ℃; for 0.5h; microwave reactor;

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 1264924-47-1
4-[(2,3-dihydro-1-imino-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

: 1264924-50-6
2,3-dihydro-1-imino-N-[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]-1H-isoindol-5-amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; 1,2-dimethoxyethane; water / 16 h / 100 °C / Inert atmosphere

2: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 110 °C / sealed tube; Inert atmosphere

3: tetra-(n-butyl)ammonium iodide; hydrogen iodide / water / 0.5 h / 100 °C / microwave reactor

With hydrogen iodide; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; toluene;