tert-butyl N-[(5-amino-2-cyanophenyl)methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate

Base Information

• Chemical Name: tert-butyl N-[(5-amino-2-cyanophenyl)methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate
• CAS No.: 1228773-19-0
• Molecular Formula: C₁₈H₂₅N₃O₄
• Molecular Weight: 347.414
• Mol file: 1228773-19-0.mol

Synonyms:tert-butyl N-[(5-amino-2-cyanophenyl)methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate

Chemical Property of tert-butyl N-[(5-amino-2-cyanophenyl)methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl N-[(5-amino-2-cyanophenyl)methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate

There total 3 articles about tert-butyl N-[(5-amino-2-cyanophenyl)methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-cyano-5-nitrotoluene (89001-53-6) → tert-butyl N-[(5-amino-2-cyanophenyl)methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate (1228773-19-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 72 h / Reflux; Inert atmosphere

2: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 20 °C

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;

Reference yield:

tert-butyl N-[(2-cyano-5-nitrophenyl)methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate (1228773-18-9) → tert-butyl N-[(5-amino-2-cyanophenyl)methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate (1228773-19-0)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

Reference yield:

2-(bromomethyl)-4-nitrobenzonitrile (852203-01-1) → tert-butyl N-[(5-amino-2-cyanophenyl)methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate (1228773-19-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 20 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran

With hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl N-[(2-cyano-5-nitrophenyl)methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate

2-(bromomethyl)-4-nitrobenzonitrile

2-cyano-5-nitrotoluene

Downstream raw materials:

C₁₈H₂₄ClN₃O₄

C₁₈H₂₄ClN₃O₄

C₃₀H₃₅N₅O₅

4-[(2,3-dihydro-1-imino-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol