4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-fluorophenyl sulfamate

Base Information

Chemical Name:4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-fluorophenyl sulfamate
CAS No.:1260389-37-4
Molecular Formula:C₂₂H₁₇FN₆O₃S
Molecular Weight:464.48
Hs Code.:

Synonyms:4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-fluorophenyl sulfamate

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Chemical Property of 4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-fluorophenyl sulfamate

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Technology Process of 4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-fluorophenyl sulfamate

There total 10 articles about 4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-fluorophenyl sulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1260389-55-6
5-((3-fluoro-4-hydroxy-benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2-carbonitrile

: 1260389-37-4
4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-fluorophenyl sulfamate

Guidance literature:: With sulphamoyl chloride; In N,N-dimethyl acetamide; at 0 - 20 ℃; for 6h;

Reference yield:

: 98-80-6
phenylboronic acid

: 1260389-37-4
4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-fluorophenyl sulfamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / Heating; Reflux; Inert atmosphere

2.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C

2.2: 1 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

3.2: 18 h / 20 °C

4.1: hydrogen / 10% palladium on activated charcoal / tetrahydrofuran; methanol / 48 h

5.1: sulphamoyl chloride / N,N-dimethyl acetamide / 6 h / 0 - 20 °C

With sulphamoyl chloride; potassium tert-butylate; hydrogen; sodium hydride; sodium carbonate; 10% palladium on activated charcoal; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1841-43-6
4-fluoro-2-phenylbenzonitrile

: 1260389-37-4
4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-fluorophenyl sulfamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

2.2: 18 h / 20 °C

3.1: hydrogen / 10% palladium on activated charcoal / tetrahydrofuran; methanol / 48 h

4.1: sulphamoyl chloride / N,N-dimethyl acetamide / 6 h / 0 - 20 °C

With sulphamoyl chloride; potassium tert-butylate; hydrogen; sodium hydride; 10% palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;