Technology Process of (E)-(methoxy-2-phenylcyclopropylidenemethyl)triethylsilane
There total 3 articles about (E)-(methoxy-2-phenylcyclopropylidenemethyl)triethylsilane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C15H23BrSi;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -90 ℃;
for 0.3h;
Inert atmosphere;
Dichloromethyl methyl ether;
In
tetrahydrofuran; hexane;
at -90 ℃;
for 0.5h;
Inert atmosphere;
With
methanol;
In
tetrahydrofuran; hexane;
at -90 ℃;
optical yield given as %de;
DOI:10.1016/j.tet.2011.10.013
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -95 °C / Inert atmosphere
1.2: 3 h / -95 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.3 h / -90 °C / Inert atmosphere
2.2: 0.5 h / -90 °C / Inert atmosphere
2.3: -90 °C
With
n-butyllithium;
In
tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2011.10.013
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium tert-butylate / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -95 °C / Inert atmosphere
2.2: 3 h / -95 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.3 h / -90 °C / Inert atmosphere
3.2: 0.5 h / -90 °C / Inert atmosphere
3.3: -90 °C
With
n-butyllithium; potassium tert-butylate;
In
tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2011.10.013
