2'-Bromo-2,6-dimethyl-1,4-dihydro-[4,4']bipyridinyl-3,5-dicarboxylic acid 5-(2-chloro-ethyl) ester 3-methyl ester

Base Information

• Chemical Name: 2'-Bromo-2,6-dimethyl-1,4-dihydro-[4,4']bipyridinyl-3,5-dicarboxylic acid 5-(2-chloro-ethyl) ester 3-methyl ester
• CAS No.: 131747-90-5
• Molecular Formula: C₁₇H₁₈BrClN₂O₄
• Molecular Weight: 429.698
• Mol file: 131747-90-5.mol

Synonyms:2'-Bromo-2,6-dimethyl-1,4-dihydro-[4,4']bipyridinyl-3,5-dicarboxylic acid 5-(2-chloro-ethyl) ester 3-methyl ester

Chemical Property of 2'-Bromo-2,6-dimethyl-1,4-dihydro-[4,4']bipyridinyl-3,5-dicarboxylic acid 5-(2-chloro-ethyl) ester 3-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-Bromo-2,6-dimethyl-1,4-dihydro-[4,4']bipyridinyl-3,5-dicarboxylic acid 5-(2-chloro-ethyl) ester 3-methyl ester

There total 1 articles about 2'-Bromo-2,6-dimethyl-1,4-dihydro-[4,4']bipyridinyl-3,5-dicarboxylic acid 5-(2-chloro-ethyl) ester 3-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromoisonicotinic acid (66572-56-3) → 2'-Bromo-2,6-dimethyl-1,4-dihydro-[4,4']bipyridinyl-3,5-dicarboxylic acid 5-(2-chloro-ethyl) ester 3-methyl ester (131747-90-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) NEt₃, ethyl chloroformate, 2) LiAlH₄ / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min

2: 88 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H₃PO₄ / 1.5 h / Ambient temperature

3: propan-2-ol / 40 °C

With lithium aluminium tetrahydride; phosphoric acid; chloroformic acid ethyl ester; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; In isopropyl alcohol;

DOI:10.1248/cpb.38.2446

Reference yield:

2'-Bromo-2,6-dimethyl-1,4-dihydro-[4,4']bipyridinyl-3,5-dicarboxylic acid 5-(2-chloro-ethyl) ester 3-methyl ester (131747-90-5) + benzyl-methyl-amine (103-67-3) → 2'-Bromo-2,6-dimethyl-1,4-dihydro-[4,4']bipyridinyl-3,5-dicarboxylic acid 5-[2-(benzyl-methyl-amino)-ethyl] ester 3-methyl ester (108338-10-9)

Guidance literature:

In N,N-dimethyl-formamide; at 100 - 105 ℃; Yield given;

DOI:10.1248/cpb.38.2446

upstream raw materials:

2-bromoisonicotinic acid

Downstream raw materials:

2'-Bromo-2,6-dimethyl-1,4-dihydro-[4,4']bipyridinyl-3,5-dicarboxylic acid 5-[2-(benzyl-methyl-amino)-ethyl] ester 3-methyl ester