5-{3-chloro-4-[(phenylmethyl)oxy]phenyl}-3-(1,1-dimethylethyl)-6-fluoro-1-methyl-7-(methyloxy)-8-{[(1-methylpiperidin-4-yl)methyl]oxy}-3H-pyrazolo[3,4-c]isoquinoline

Base Information

Chemical Name:5-{3-chloro-4-[(phenylmethyl)oxy]phenyl}-3-(1,1-dimethylethyl)-6-fluoro-1-methyl-7-(methyloxy)-8-{[(1-methylpiperidin-4-yl)methyl]oxy}-3H-pyrazolo[3,4-c]isoquinoline
CAS No.:838856-97-6
Molecular Formula:C₃₆H₄₀ClFN₄O₃
Molecular Weight:631.19
Hs Code.:

5-{3-chloro-4-[(phenylmethyl)oxy]phenyl}-3-(1,1-dimethylethyl)-6-fluoro-1-methyl-7-(methyloxy)-8-{[(1-methylpiperidin-4-yl)methyl]oxy}-3H-pyrazolo[3,4-c]isoquinoline

Synonyms:5-{3-chloro-4-[(phenylmethyl)oxy]phenyl}-3-(1,1-dimethylethyl)-6-fluoro-1-methyl-7-(methyloxy)-8-{[(1-methylpiperidin-4-yl)methyl]oxy}-3H-pyrazolo[3,4-c]isoquinoline

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Chemical Property of 5-{3-chloro-4-[(phenylmethyl)oxy]phenyl}-3-(1,1-dimethylethyl)-6-fluoro-1-methyl-7-(methyloxy)-8-{[(1-methylpiperidin-4-yl)methyl]oxy}-3H-pyrazolo[3,4-c]isoquinoline

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Technology Process of 5-{3-chloro-4-[(phenylmethyl)oxy]phenyl}-3-(1,1-dimethylethyl)-6-fluoro-1-methyl-7-(methyloxy)-8-{[(1-methylpiperidin-4-yl)methyl]oxy}-3H-pyrazolo[3,4-c]isoquinoline

There total 15 articles about 5-{3-chloro-4-[(phenylmethyl)oxy]phenyl}-3-(1,1-dimethylethyl)-6-fluoro-1-methyl-7-(methyloxy)-8-{[(1-methylpiperidin-4-yl)methyl]oxy}-3H-pyrazolo[3,4-c]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: C₃₅H₃₈ClFN₄O₃

: 838856-97-6
5-{3-chloro-4-[(phenylmethyl)oxy]phenyl}-3-(1,1-dimethylethyl)-6-fluoro-1-methyl-7-(methyloxy)-8-{[(1-methylpiperidin-4-yl)methyl]oxy}-3H-pyrazolo[3,4-c]isoquinoline

Guidance literature:: With sodium tris(acetoxy)borohydride; In water; 1,2-dichloro-ethane; at 20 ℃; for 1h;

Reference yield:

: 838856-88-5
3-fluoro-5-hydroxy-4-methoxybenzoic acid methyl ester

: 838856-97-6
5-{3-chloro-4-[(phenylmethyl)oxy]phenyl}-3-(1,1-dimethylethyl)-6-fluoro-1-methyl-7-(methyloxy)-8-{[(1-methylpiperidin-4-yl)methyl]oxy}-3H-pyrazolo[3,4-c]isoquinoline

Guidance literature:: Multi-step reaction with 11 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

3.1: pyridine; thionyl chloride / dichloromethane / 0.08 h / 0 - 20 °C

4.1: N,N-dimethyl-formamide / 12 h / 20 °C

5.1: sodium hydride / tetrahydrofuran / 0.58 h / 0 - 20 °C

6.1: ethanol / 12 h / 75 °C

7.1: hydrogen / palladium 10% on activated carbon / ethanol / 9 h / 20 °C / 2585.81 Torr

7.2: pH 7

8.1: acetic acid / 19 h / 90 °C

8.2: 90 °C

9.1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 90 °C

10.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

10.2: pH 10

11.1: sodium tris(acetoxy)borohydride / water; 1,2-dichloro-ethane / 1 h / 20 °C

With pyridine; lithium aluminium tetrahydride; thionyl chloride; hydrogen; sodium tris(acetoxy)borohydride; sodium hydride; caesium carbonate; acetic acid; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 838856-91-0
5-(chloromethyl)-1-fluoro-2-(methyloxy)-3-[(phenylmethyl)oxy]benzene

: 838856-97-6
5-{3-chloro-4-[(phenylmethyl)oxy]phenyl}-3-(1,1-dimethylethyl)-6-fluoro-1-methyl-7-(methyloxy)-8-{[(1-methylpiperidin-4-yl)methyl]oxy}-3H-pyrazolo[3,4-c]isoquinoline

Guidance literature:: Multi-step reaction with 8 steps

1.1: N,N-dimethyl-formamide / 12 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.58 h / 0 - 20 °C

3.1: ethanol / 12 h / 75 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 9 h / 20 °C / 2585.81 Torr

4.2: pH 7

5.1: acetic acid / 19 h / 90 °C

5.2: 90 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 90 °C

7.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

7.2: pH 10

8.1: sodium tris(acetoxy)borohydride / water; 1,2-dichloro-ethane / 1 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; sodium hydride; caesium carbonate; acetic acid; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;