Technology Process of 1,3-dibromo-5-(ferrocenylethynyl)benzene
There total 2 articles about 1,3-dibromo-5-(ferrocenylethynyl)benzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
PdCl2(P(C6H5)3)2; CuI;
In
further solvent(s);
(N2); addn. of palladium compd. and copper iodide to soln. of ferrocene deriv. and benzene deriv. in diisopropylamine at 0°C, stirring for 2 h at 0°C, stirring at 25°C overnight; filtration through celite, evapn., chromy. (alumina, petroleum ether/CH2Cl2 (4:1)), elem. anal.;
DOI:10.1021/om800206k
- Guidance literature:
-
With
PPh3; iPr2NH;
copper(l) iodide; palladium(II) acetate;
In
neat (no solvent);
N2-atmosphere; stirring (0°C, 10 min), refluxing (2 h); filtering, evapn., washing (HCl, Na2CO3, H2O), chromy. (alumina, hexane / CH2Cl2 = 4 : 1), evapn. (vac.); elem. anal.;
DOI:10.1021/om9701027
- Guidance literature:
-
With
n-BuLi; sodium thiosulfate;
In
tetrahydrofuran; hexane;
Schlenk technique, under Ar; soln. of n-BuLi (2.25 mmol) (hexane) added slowly to soln. of Fe complex (2.25 mmol) (THF) at -80°C, stirredfor 1.5 h, soln. of I2 (2.56 mmol) (THF) added, stirred at 25°C for 1 h, aq. soln. of Na2S2O3 added; extracted with CH2Cl2, extracts dried with MgSO4, volatiles removed in vac., elem. anal.;
DOI:10.1002/zaac.201000243
