N-(4-amino-2-benzoylphenyl)-2-(4-methylphenyl)acetic acid amide

Base Information

• Chemical Name: N-(4-amino-2-benzoylphenyl)-2-(4-methylphenyl)acetic acid amide
• CAS No.: 265648-28-0
• Molecular Formula: C₂₂H₂₀N₂O₂
• Molecular Weight: 344.413
• Mol file: 265648-28-0.mol

Synonyms:N-(4-amino-2-benzoylphenyl)-2-(4-methylphenyl)acetic acid amide

Chemical Property of N-(4-amino-2-benzoylphenyl)-2-(4-methylphenyl)acetic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-amino-2-benzoylphenyl)-2-(4-methylphenyl)acetic acid amide

There total 3 articles about N-(4-amino-2-benzoylphenyl)-2-(4-methylphenyl)acetic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-(2-benzoyl-4-nitrophenyl)-2-(4-methylphenyl)acetic acid amide (265648-27-9) → N-(4-amino-2-benzoylphenyl)-2-(4-methylphenyl)acetic acid amide (265648-28-0)

Guidance literature:

With tin(ll) chloride; In ethyl acetate; for 2h; Heating;

DOI:10.1016/S0223-5234(00)00162-8

Reference yield:

4-methylphenylacetyl chloride (35675-44-6) → N-(4-amino-2-benzoylphenyl)-2-(4-methylphenyl)acetic acid amide (265648-28-0)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene; dioxane / 2 h / Heating

2: SnCl₂*2H₂O / ethyl acetate / 2 h / Heating

With tin(ll) chloride; In 1,4-dioxane; ethyl acetate; toluene;

DOI:10.1016/S0960-894X(01)00798-3 DOI:10.1016/S0960-894X(02)01003-X

Reference yield:

2-amino-5-nitrobenzophenone (1775-95-7) → N-(4-amino-2-benzoylphenyl)-2-(4-methylphenyl)acetic acid amide (265648-28-0)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene; dioxane / 2 h / Heating

2: SnCl₂*2H₂O / ethyl acetate / 2 h / Heating

With tin(ll) chloride; In 1,4-dioxane; ethyl acetate; toluene;

DOI:10.1016/S0960-894X(01)00798-3 DOI:10.1016/S0960-894X(02)01003-X

upstream raw materials:

N-(2-benzoyl-4-nitrophenyl)-2-(4-methylphenyl)acetic acid amide

4-methylphenylacetyl chloride

2-amino-5-nitrobenzophenone

Downstream raw materials:

N-[3-benzoyl-4-(2-p-tolyl-acetylamino)-phenyl]-succinamic acid

4-[3-benzoyl-4-(2-p-tolyl-acetylamino)-phenylcarbamoyl]-butyric acid