(2S,3S)-2-(benzyloxymethoxy)-4-(tert-butyldimethylsiloxy)-3-(octadecanoylamino)-1-butanol

Base Information

Chemical Name:(2S,3S)-2-(benzyloxymethoxy)-4-(tert-butyldimethylsiloxy)-3-(octadecanoylamino)-1-butanol
CAS No.:147909-97-5
Molecular Formula:C₃₆H₆₇NO₅Si
Molecular Weight:622.017
Hs Code.:

Synonyms:(2S,3S)-2-(benzyloxymethoxy)-4-(tert-butyldimethylsiloxy)-3-(octadecanoylamino)-1-butanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-2-(benzyloxymethoxy)-4-(tert-butyldimethylsiloxy)-3-(octadecanoylamino)-1-butanol

Chemical Property:

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Technology Process of (2S,3S)-2-(benzyloxymethoxy)-4-(tert-butyldimethylsiloxy)-3-(octadecanoylamino)-1-butanol

There total 5 articles about (2S,3S)-2-(benzyloxymethoxy)-4-(tert-butyldimethylsiloxy)-3-(octadecanoylamino)-1-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 147909-97-5
(2S,3S)-2-(benzyloxymethoxy)-4-(tert-butyldimethylsiloxy)-3-(octadecanoylamino)-1-butanol

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / iPr₂NEt / CH₂Cl₂ / 8 h / 0 deg C to RT

2: 1) Ph₃P, 2) H₂O / 1) benzene, 45 deg C, 30 min, 2) 45 deg C, 11 h

3: Et₃N, DMAP / CH₂Cl₂ / 1) 0 deg C, 1 h, 2) RT, 5 h

4: 82 percent / LiI, NaBH₄ / tetrahydrofuran / 3 h / 35 - 40 °C

5: 1) NaH / 1) THF, RT, 45 min, 2) THF, RT, 45 min

With dmap; sodium tetrahydroborate; water; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium iodide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 147909-94-2
(2S,3R)-2-Amino-3-benzyloxymethoxy-succinic acid diethyl ester

: 147909-97-5
(2S,3S)-2-(benzyloxymethoxy)-4-(tert-butyldimethylsiloxy)-3-(octadecanoylamino)-1-butanol

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N, DMAP / CH₂Cl₂ / 1) 0 deg C, 1 h, 2) RT, 5 h

2: 82 percent / LiI, NaBH₄ / tetrahydrofuran / 3 h / 35 - 40 °C

3: 1) NaH / 1) THF, RT, 45 min, 2) THF, RT, 45 min

With dmap; sodium tetrahydroborate; sodium hydride; triethylamine; lithium iodide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 147909-93-1
diethyl (2R,3S)-2-azido-3-(benzyloxymethoxy)butane-1,4-dioate

: 147909-97-5
(2S,3S)-2-(benzyloxymethoxy)-4-(tert-butyldimethylsiloxy)-3-(octadecanoylamino)-1-butanol

Guidance literature:: Multi-step reaction with 4 steps

1: 1) Ph₃P, 2) H₂O / 1) benzene, 45 deg C, 30 min, 2) 45 deg C, 11 h

2: Et₃N, DMAP / CH₂Cl₂ / 1) 0 deg C, 1 h, 2) RT, 5 h

3: 82 percent / LiI, NaBH₄ / tetrahydrofuran / 3 h / 35 - 40 °C

4: 1) NaH / 1) THF, RT, 45 min, 2) THF, RT, 45 min

With dmap; sodium tetrahydroborate; water; sodium hydride; triethylamine; triphenylphosphine; lithium iodide; In tetrahydrofuran; dichloromethane;