tert-butyl but-3-en-1-yl(2-(((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate

Base Information

Chemical Name:tert-butyl but-3-en-1-yl(2-(((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate
CAS No.:1403480-48-7
Molecular Formula:C₄₅H₆₅FN₄O₁₀SSi
Molecular Weight:901.182
Hs Code.:

tert-butyl but-3-en-1-yl(2-(((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate

Synonyms:tert-butyl but-3-en-1-yl(2-(((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate

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Chemical Property of tert-butyl but-3-en-1-yl(2-(((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate

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Technology Process of tert-butyl but-3-en-1-yl(2-(((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate

There total 8 articles about tert-butyl but-3-en-1-yl(2-(((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1403480-49-8
C₄₀H₅₇FN₄O₈SSi

: 1403480-48-7
tert-butyl but-3-en-1-yl(2-(((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate

Guidance literature:: With dmap; for 1h; Reflux;

Reference yield:

: 1403480-39-6
N-((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)-2-fluoro-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzamide

: 1403480-48-7
tert-butyl but-3-en-1-yl(2-(((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 7 h / 20 - 35 °C

2: dmap / 1 h / Reflux

With dmap; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

Reference yield:

: C₃₀H₅₆N₂O₆Si₂

: 1403480-48-7
tert-butyl but-3-en-1-yl(2-(((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / tetrahydrofuran; methanol; water / 3 h / 20 °C

2: 2,6-dimethylpyridine / dichloromethane / 18 h / 20 °C

3: dimethylsulfide borane complex / tetrahydrofuran / 6.25 h / 0 - 65 °C / Inert atmosphere

4: triethylamine / dichloromethane / 3.5 h / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 7 h / 20 - 35 °C

6: dmap / tetrahydrofuran / 1 h / Reflux

With 2,6-dimethylpyridine; dmap; dimethylsulfide borane complex; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm500994n