N-(((8R,9R)-14-(3-(3,5-dimethylisoxazol-4-yl)ureido)-11-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-9-methyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1H-benzo[g][1,5,9]oxadiazacyclotetradecin-8-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Base Information

Chemical Name:N-(((8R,9R)-14-(3-(3,5-dimethylisoxazol-4-yl)ureido)-11-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-9-methyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1H-benzo[g][1,5,9]oxadiazacyclotetradecin-8-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide
CAS No.:1403478-61-4
Molecular Formula:C₄₁H₅₃FN₆O₈S
Molecular Weight:808.972
Hs Code.:

N-(((8R,9R)-14-(3-(3,5-dimethylisoxazol-4-yl)ureido)-11-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-9-methyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1H-benzo[g][1,5,9]oxadiazacyclotetradecin-8-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Synonyms:N-(((8R,9R)-14-(3-(3,5-dimethylisoxazol-4-yl)ureido)-11-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-9-methyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1H-benzo[g][1,5,9]oxadiazacyclotetradecin-8-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

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Chemical Property of N-(((8R,9R)-14-(3-(3,5-dimethylisoxazol-4-yl)ureido)-11-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-9-methyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1H-benzo[g][1,5,9]oxadiazacyclotetradecin-8-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

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Technology Process of N-(((8R,9R)-14-(3-(3,5-dimethylisoxazol-4-yl)ureido)-11-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-9-methyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1H-benzo[g][1,5,9]oxadiazacyclotetradecin-8-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

There total 17 articles about N-(((8R,9R)-14-(3-(3,5-dimethylisoxazol-4-yl)ureido)-11-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-9-methyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1H-benzo[g][1,5,9]oxadiazacyclotetradecin-8-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403481-60-6
C₃₅H₄₇FN₄O₆S

: 131825-41-7
3,5-dimethylisoxazol4-yl isocyanate

: 1403478-61-4
N-(((8R,9R)-14-(3-(3,5-dimethylisoxazol-4-yl)ureido)-11-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-9-methyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1H-benzo[g][1,5,9]oxadiazacyclotetradecin-8-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Guidance literature:: In dichloromethane; for 16h; Inert atmosphere;

Reference yield:

: 4-fluoro-N-(((8R,9R)-11-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-9-methyl-14-nitro-12-oxo-2,3,6,8,9,10,11,12-octahydro-1H-benzo[g][1,5,9]oxadiazacyclotetradecin-8-yl)methyl)-N-methylbenzenesulfonamide

: 1403478-61-4
N-(((8R,9R)-14-(3-(3,5-dimethylisoxazol-4-yl)ureido)-11-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-9-methyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1H-benzo[g][1,5,9]oxadiazacyclotetradecin-8-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

2: tin(II) chloride dihdyrate / ethanol / 36 h / 20 °C

3: dichloromethane / 16 h / Inert atmosphere

With tin(II) chloride dihdyrate; hydrogen; palladium 10% on activated carbon; In ethanol; dichloromethane;

Reference yield:

: C₃₅H₄₅FN₄O₈S

: 1403478-61-4
N-(((8R,9R)-14-(3-(3,5-dimethylisoxazol-4-yl)ureido)-11-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-9-methyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1H-benzo[g][1,5,9]oxadiazacyclotetradecin-8-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: tin(II) chloride dihdyrate / ethanol / 36 h / 20 °C

2: dichloromethane / 16 h / Inert atmosphere

With tin(II) chloride dihdyrate; In ethanol; dichloromethane;