N-[8-Methoxy-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-4-yl]-acetamide

Base Information

Chemical Name:N-[8-Methoxy-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-4-yl]-acetamide
CAS No.:200010-64-6
Molecular Formula:C₂₀H₂₂N₂O₅S
Molecular Weight:402.471
Hs Code.:

Synonyms:N-[8-Methoxy-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-4-yl]-acetamide

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Chemical Property of N-[8-Methoxy-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-4-yl]-acetamide

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Technology Process of N-[8-Methoxy-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-4-yl]-acetamide

There total 15 articles about N-[8-Methoxy-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-4-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 108-24-7
acetic anhydride

: 200010-59-9
8-Methoxy-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-benzo[b]azepine-4,5-dione 4-oxime

: 200010-64-6
N-[8-Methoxy-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-4-yl]-acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; under 2327.2 Torr;

Reference yield:

: 52351-75-4
6-methoxyisatin

: 200010-64-6
N-[8-Methoxy-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-4-yl]-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 78 percent / aq. NaOH, 30percent H₂O₂ / 24 h / Ambient temperature

2: 5 percent / BF₃*MeOH / 18 h / Heating

3: 94 percent / pyridine / Ambient temperature

4: 74 percent / NaH / dimethylformamide / 1.) r.t., 2 h, 2.) 80 deg C, 26 h

5: 70 percent / conc. aq. HCl / acetic acid; ethanol / 24 h / Heating

6: 91 percent / isoamyl nitrite, HCl / diethyl ether / 1 h / Ambient temperature

7: 67 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 2327.2 Torr

With pyridine; hydrogenchloride; sodium hydroxide; hydrogen; dihydrogen peroxide; boron trifluoride methanol complex; sodium hydride; isopentyl nitrite; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 17422-43-4
8-methoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine

: 200010-64-6
N-[8-Methoxy-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-4-yl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / pyridine / 3 h / Ambient temperature

2: 74 percent / CrO₃, aq. AcOH / Ambient temperature

3: 91 percent / isoamyl nitrite, HCl / diethyl ether / 1 h / Ambient temperature

4: 67 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 2327.2 Torr

With pyridine; chromium(VI) oxide; hydrogenchloride; hydrogen; acetic acid; isopentyl nitrite; palladium on activated charcoal; In tetrahydrofuran; diethyl ether;