52351-75-4 Usage
Uses
Used in Organic Synthesis:
6-METHOXY-2,3-DIOXYINDOLE is used as a key intermediate in the synthesis of various organic compounds due to its reactive functional groups, which can be further modified to produce a range of derivatives with diverse properties and applications.
Used in Pharmaceutical Research:
6-METHOXY-2,3-DIOXYINDOLE is utilized as a starting material or a building block in the development of new pharmaceutical agents. Its unique structure and potential biological activities make it a valuable candidate for the creation of novel drugs with specific therapeutic targets.
Used in Chemical Research:
6-METHOXY-2,3-DIOXYINDOLE serves as a subject of study in chemical research to explore its properties, reactivity, and potential interactions with other molecules. This research can contribute to a deeper understanding of the indole class of compounds and their role in various chemical processes.
Used in Material Science:
6-METHOXY-2,3-DIOXYINDOLE may find applications in the development of new materials with specific properties, such as conductivity, magnetism, or optical characteristics, owing to its unique molecular structure and functional groups.
Used in Environmental Science:
6-METHOXY-2,3-DIOXYINDOLE could be employed in environmental applications, such as the detection or remediation of pollutants, based on its chemical properties and potential interactions with contaminants.
Used in Analytical Chemistry:
6-METHOXY-2,3-DIOXYINDOLE may be used as a reference compound or a standard in analytical chemistry for the development and validation of analytical methods, such as chromatography, spectroscopy, or electrochemistry, due to its well-defined chemical structure and properties.
Check Digit Verification of cas no
The CAS Registry Mumber 52351-75-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,3,5 and 1 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 52351-75:
(7*5)+(6*2)+(5*3)+(4*5)+(3*1)+(2*7)+(1*5)=104
104 % 10 = 4
So 52351-75-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H7NO3/c1-13-5-2-3-6-7(4-5)10-9(12)8(6)11/h2-4H,1H3,(H,10,11,12)
52351-75-4Relevant academic research and scientific papers
Synthesis and characterization of 3-arylquinazolinone and 3-arylquinazolinethione derivatives as selective estrogen receptor beta modulators
Güng?r, Timur,Chen, Ying,Golla, Rajasree,Ma, Zhengping,Corte, James R.,Northrop, John P.,Bin, Bin,Dickson, John K.,Stouch, Terry,Zhou, Rong,Johnson, Susan E.,Seethala, Ramakrishna,Feyen, Jean H. M.
, p. 2440 - 2455 (2007/10/03)
On the basis of the structure of genistein, a new series of 3-arylquinazolines was prepared and tested for their estrogen receptor (ER) α and β affinities. 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4(3H)- quinazolinone (1aa) acts as an agonist on both ER subtypes. It has 62-fold higher binding affinity [IC50(ERβ) = 179 nM] and 38-fold higher functional potency in a transcription assay [EC50(ERβ) = 76 nM] with ERβ than with ERα, thus improving upon the selectivity of genistein. All of the analogues showed preferential binding affinity for ERβ. Many are also more potent in activating transcription by ERβ than by ERα. Transformation of the C=O functionality at position 4 into a C=S group provided 5,7-dihydroxy-3-(4-hydroxyphenyl)-4(3H)-quinazolinethione (1ba), which acts as an agonist on both ER subtypes but has 56-fold higher binding affinity for ERβ over ERα [IC50(ERβ) = 47 nM] and 215-fold higher potency in the transcription assay [EC50(ERβ) = 13 nM]. These ERβ-selective compounds may represent valuable tools in understanding the differences in structure and biological function of ERβ and ERα.
