N-(4-ethanamidobutyl)-3-(4-hydroxyphenyl)-N-(3-(3-(4-hydroxyphenyl)propanamido)propyl)propanamide

Base Information

Chemical Name:N-(4-ethanamidobutyl)-3-(4-hydroxyphenyl)-N-(3-(3-(4-hydroxyphenyl)propanamido)propyl)propanamide
CAS No.:1354794-12-9
Molecular Formula:C₂₇H₃₇N₃O₅
Molecular Weight:483.608
Hs Code.:

Synonyms:N-(4-ethanamidobutyl)-3-(4-hydroxyphenyl)-N-(3-(3-(4-hydroxyphenyl)propanamido)propyl)propanamide

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Chemical Property of N-(4-ethanamidobutyl)-3-(4-hydroxyphenyl)-N-(3-(3-(4-hydroxyphenyl)propanamido)propyl)propanamide

Chemical Property:

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Technology Process of N-(4-ethanamidobutyl)-3-(4-hydroxyphenyl)-N-(3-(3-(4-hydroxyphenyl)propanamido)propyl)propanamide

There total 6 articles about N-(4-ethanamidobutyl)-3-(4-hydroxyphenyl)-N-(3-(3-(4-hydroxyphenyl)propanamido)propyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 4-(3-((4-ethanamidobutyl)(3-(3-(4-(tosyloxy)phenyl)propanamido)propyl)amino)-3-oxopropyl)phenyl 4-methylbenzenesulfonate

: 1354794-12-9
N-(4-ethanamidobutyl)-3-(4-hydroxyphenyl)-N-(3-(3-(4-hydroxyphenyl)propanamido)propyl)propanamide

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 24h; Reflux;
DOI:10.1016/j.tetlet.2015.11.020

Reference yield:

: 3-(4-(tosyloxy)phenyl)propanoic acid

: 1354794-12-9
N-(4-ethanamidobutyl)-3-(4-hydroxyphenyl)-N-(3-(3-(4-hydroxyphenyl)propanamido)propyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

1.2: 20 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

3.1: dichloromethane / 20 °C

4.1: sodium hydroxide / methanol / 24 h / 20 °C / Reflux

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane;
DOI:10.1016/j.tetlet.2015.11.020

Reference yield:

: 103493-34-1
[4-(3-aminopropylamino)butyl]carbamic acid tert-butyl ester

: 1354794-12-9
N-(4-ethanamidobutyl)-3-(4-hydroxyphenyl)-N-(3-(3-(4-hydroxyphenyl)propanamido)propyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

1.2: 20 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

3.1: dichloromethane / 20 °C

4.1: sodium hydroxide / methanol / 24 h / 20 °C / Reflux

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane;
DOI:10.1016/j.tetlet.2015.11.020