Technology Process of tert-Butyl-dimethyl-{(4E,8E)-(2R,6S,10S,11R)-2,6,10-trimethyl-11-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-nonyloxy)-benzyloxy]-dodeca-4,8-dienyloxy}-silane
There total 22 articles about tert-Butyl-dimethyl-{(4E,8E)-(2R,6S,10S,11R)-2,6,10-trimethyl-11-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-nonyloxy)-benzyloxy]-dodeca-4,8-dienyloxy}-silane which
guide to synthetic route it.
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synthetic route:
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780772-57-8
tert-Butyl-dimethyl-{(4E,8E)-(2R,6S,10S,11R)-2,6,10-trimethyl-11-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-nonyloxy)-benzyloxy]-dodeca-4,8-dienyloxy}-silane
- Guidance literature:
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Multi-step reaction with 2 steps
1.1: 5.28 g / hydrogen peroxide / (NH4)6Mo7O24*4H2O / tetrahydrofuran; ethanol / 14 h / 20 °C
2.1: sodium hexamethyldisilazide / tetrahydrofuran / 0.5 h / -78 °C
2.2: tetrahydrofuran / 2 h / -78 °C
With
dihydrogen peroxide; sodium hexamethyldisilazane;
ammonium heptamolybdate;
In
tetrahydrofuran; ethanol;
2.2: Kocienski-Julia olefination;
DOI:10.1021/jo051526a
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780772-57-8
tert-Butyl-dimethyl-{(4E,8E)-(2R,6S,10S,11R)-2,6,10-trimethyl-11-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-nonyloxy)-benzyloxy]-dodeca-4,8-dienyloxy}-silane
- Guidance literature:
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Multi-step reaction with 5 steps
1.1: 3.76 g / hydrogen peroxide / (NH4)6Mo7O24*4H2O / tetrahydrofuran; ethanol / 14 h / 20 °C
2.1: sodium hexamethyldisilazide / tetrahydrofuran / 0.5 h / -78 °C
2.2: tetrahydrofuran / 2 h / -78 °C
3.1: TBAF / tetrahydrofuran / 3 h / 20 °C
4.1: Dess-Martin periodinane / CH2Cl2 / 3 h / 20 °C
5.1: sodium hexamethyldisilazide / tetrahydrofuran / 0.5 h / -78 °C
5.2: tetrahydrofuran / 2 h / -78 °C
With
tetrabutyl ammonium fluoride; dihydrogen peroxide; sodium hexamethyldisilazane; Dess-Martin periodane;
ammonium heptamolybdate;
In
tetrahydrofuran; ethanol; dichloromethane;
2.2: Kocienski-Julia olefination / 4.1: Dess-Martin oxidation / 5.2: Kocienski-Julia olefination;
DOI:10.1021/jo051526a
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780772-57-8
tert-Butyl-dimethyl-{(4E,8E)-(2R,6S,10S,11R)-2,6,10-trimethyl-11-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-nonyloxy)-benzyloxy]-dodeca-4,8-dienyloxy}-silane
- Guidance literature:
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Multi-step reaction with 8 steps
1.1: 96 percent / CH2Cl2; hexane / -40 - 20 °C
2.1: 92 percent / DMAP / CH2Cl2 / 16 h / 20 °C
3.1: 96 percent / dimethylformamide / 17 h / 60 °C
4.1: 93 percent / DIBAL / CH2Cl2; hexane / 2 h / -20 °C
5.1: 97 percent / sodium borohydride / methanol; H2O / 1 h / -20 °C
6.1: diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / 20 °C
7.1: 5.28 g / hydrogen peroxide / (NH4)6Mo7O24*4H2O / tetrahydrofuran; ethanol / 14 h / 20 °C
8.1: sodium hexamethyldisilazide / tetrahydrofuran / 0.5 h / -78 °C
8.2: tetrahydrofuran / 2 h / -78 °C
With
dmap; sodium tetrahydroborate; di-isopropyl azodicarboxylate; dihydrogen peroxide; sodium hexamethyldisilazane; diisobutylaluminium hydride; triphenylphosphine;
ammonium heptamolybdate;
In
tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
6.1: Mitsunobu reaction / 8.2: Kocienski-Julia olefination;
DOI:10.1021/jo051526a