(3R)-5-[4-(tert-butyldimethylsilanyloxy)-3-methylbutane-1-sulfonyl]-1-phenyl-1H-tetrazole

Base Information

Chemical Name:(3R)-5-[4-(tert-butyldimethylsilanyloxy)-3-methylbutane-1-sulfonyl]-1-phenyl-1H-tetrazole
CAS No.:780772-17-0
Molecular Formula:C₁₈H₃₀N₄O₃SSi
Molecular Weight:410.613
Hs Code.:

Synonyms:(3R)-5-[4-(tert-butyldimethylsilanyloxy)-3-methylbutane-1-sulfonyl]-1-phenyl-1H-tetrazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R)-5-[4-(tert-butyldimethylsilanyloxy)-3-methylbutane-1-sulfonyl]-1-phenyl-1H-tetrazole

Chemical Property:

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Technology Process of (3R)-5-[4-(tert-butyldimethylsilanyloxy)-3-methylbutane-1-sulfonyl]-1-phenyl-1H-tetrazole

There total 8 articles about (3R)-5-[4-(tert-butyldimethylsilanyloxy)-3-methylbutane-1-sulfonyl]-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-butylsulfanyl]-1-phenyl-1H-tetrazole

: 780772-17-0
(3R)-5-[4-(tert-butyldimethylsilanyloxy)-3-methylbutane-1-sulfonyl]-1-phenyl-1H-tetrazole

Guidance literature:: With dihydrogen peroxide; ammonium heptamolybdate; In tetrahydrofuran; ethanol; at 20 ℃; for 14h;
DOI:10.1021/jo051526a

Reference yield:

: 112057-64-4
(R)-3-(tert-butyldimethylsilyloxy)-2-methylpropan-1-ol

: 780772-17-0
(3R)-5-[4-(tert-butyldimethylsilanyloxy)-3-methylbutane-1-sulfonyl]-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / DMAP / CH₂Cl₂ / 16 h / 20 °C

2: 96 percent / dimethylformamide / 17 h / 60 °C

3: 93 percent / DIBAL / CH₂Cl₂; hexane / 2 h / -20 °C

4: 97 percent / sodium borohydride / methanol; H₂O / 1 h / -20 °C

5: diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / 20 °C

6: 5.28 g / hydrogen peroxide / (NH₄)6Mo₇O₂₄*4H₂O / tetrahydrofuran; ethanol / 14 h / 20 °C

With dmap; sodium tetrahydroborate; di-isopropyl azodicarboxylate; dihydrogen peroxide; diisobutylaluminium hydride; triphenylphosphine; ammonium heptamolybdate; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; 5: Mitsunobu reaction;
DOI:10.1021/jo051526a

Reference yield:

: 93454-85-4
(S)-3-(tert-butyldimethylsilyloxy)-2-methylpropionic acid methyl ester

: 780772-17-0
(3R)-5-[4-(tert-butyldimethylsilanyloxy)-3-methylbutane-1-sulfonyl]-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / CH₂Cl₂; hexane / -40 - 20 °C

2: 92 percent / DMAP / CH₂Cl₂ / 16 h / 20 °C

3: 96 percent / dimethylformamide / 17 h / 60 °C

4: 93 percent / DIBAL / CH₂Cl₂; hexane / 2 h / -20 °C

5: 97 percent / sodium borohydride / methanol; H₂O / 1 h / -20 °C

6: diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / 20 °C

7: 5.28 g / hydrogen peroxide / (NH₄)6Mo₇O₂₄*4H₂O / tetrahydrofuran; ethanol / 14 h / 20 °C

With dmap; sodium tetrahydroborate; di-isopropyl azodicarboxylate; dihydrogen peroxide; diisobutylaluminium hydride; triphenylphosphine; ammonium heptamolybdate; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; 6: Mitsunobu reaction;
DOI:10.1021/jo051526a