4-amino-6-{4-[trans-4-(2-amino-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

Base Information

Chemical Name:4-amino-6-{4-[trans-4-(2-amino-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one
CAS No.:1236356-03-8
Molecular Formula:C₂₃H₃₁N₅O₂
Molecular Weight:409.531
Hs Code.:

Synonyms:4-amino-6-{4-[trans-4-(2-amino-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

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Chemical Property of 4-amino-6-{4-[trans-4-(2-amino-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

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Technology Process of 4-amino-6-{4-[trans-4-(2-amino-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

There total 3 articles about 4-amino-6-{4-[trans-4-(2-amino-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1236357-76-8
C₂₃H₂₉N₇O₂

: 1236356-03-8
4-amino-6-{4-[trans-4-(2-amino-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; ethyl acetate; for 20h; under 2585.81 Torr;

Reference yield:

: 1236356-01-6
4-amino-6-{4-[trans-4-(2-hydroxy-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

: 1236356-03-8
4-amino-6-{4-[trans-4-(2-amino-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

Guidance literature:: 4-amino-6-{4-[trans-4-(2-hydroxy-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one; With trimethylsilylazide; boron trifluoride diethyl etherate; for 30h;

With palladium 10% on activated carbon; hydrogen; In ethanol; ethyl acetate; for 20h; under 2585.81 Torr;
DOI:10.1016/j.bmc.2013.06.045

Reference yield:

: 1109276-87-0
methyl {trans-4-[4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-(5H)-yl)phenyl]cyclohexyl}acetate

: 1236356-03-8
4-amino-6-{4-[trans-4-(2-amino-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 20 °C / Cooling with ice

2.1: trimethylsilylazide; boron trifluoride diethyl etherate / 30 h

2.2: 20 h / 2585.81 Torr

With trimethylsilylazide; boron trifluoride diethyl etherate; In toluene;
DOI:10.1016/j.bmc.2013.06.045