4-amino-6-{4-[trans-4-(2-hydroxy-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

Base Information

• Chemical Name: 4-amino-6-{4-[trans-4-(2-hydroxy-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one
• CAS No.: 1236356-01-6
• Molecular Formula: C₂₃H₃₀N₄O₃
• Molecular Weight: 410.516

Synonyms:4-amino-6-{4-[trans-4-(2-hydroxy-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

Chemical Property of 4-amino-6-{4-[trans-4-(2-hydroxy-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

Chemical Property:

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Technology Process of 4-amino-6-{4-[trans-4-(2-hydroxy-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

There total 1 articles about 4-amino-6-{4-[trans-4-(2-hydroxy-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl {trans-4-[4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-(5H)-yl)phenyl]cyclohexyl}acetate (1109276-87-0) + methylmagnesium bromide (75-16-1) → 4-amino-6-{4-[trans-4-(2-hydroxy-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one (1236356-01-6)

Guidance literature:

methyl {trans-4-[4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-(5H)-yl)phenyl]cyclohexyl}acetate; methylmagnesium bromide; In toluene; Cooling with ice;

With water; In ethyl acetate; toluene;

Reference yield:

4-amino-6-{4-[trans-4-(2-hydroxy-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one (1236356-01-6) → 4-amino-6-{4-[trans-4-(2-amino-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one (1236356-03-8)

Guidance literature:

4-amino-6-{4-[trans-4-(2-hydroxy-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one; With trimethylsilylazide; boron trifluoride diethyl etherate; for 30h;

With palladium 10% on activated carbon; hydrogen; In ethanol; ethyl acetate; for 20h; under 2585.81 Torr;

DOI:10.1016/j.bmc.2013.06.045

Reference yield:

4-amino-6-{4-[trans-4-(2-hydroxy-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one (1236356-01-6) → C23H29N7O2 (1236357-76-8)

Guidance literature:

With trimethylsilylazide; boron trifluoride diethyl etherate;

upstream raw materials:

methyl {trans-4-[4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-(5H)-yl)phenyl]cyclohexyl}acetate

methylmagnesium bromide

Downstream raw materials:

C₂₃H₂₉N₇O₂

4-amino-6-{4-[trans-4-(2-amino-2-methylpropyl)cyclohexyl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

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