Technology Process of (Z)-4-(phenylthio)-3,5-hexadienoic acid
There total 6 articles about (Z)-4-(phenylthio)-3,5-hexadienoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 100 percent / KOH / methanol / 12 h / 25 °C
2: 1.) diisopropylamine, sec-Bu-Li, 2.) HMPA / 1.) THF, cyclohexane, 30 min, -78 deg C; 2.) THF, 2 h, -78 deg C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sec.-butyllithium; diisopropylamine;
In
methanol;
DOI:10.1021/jo00152a012
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 50 percent / methanesulfonyl chloride / triethylamine / 18 h / 25 °C
2: 100 percent / KOH / methanol / 12 h / 25 °C
3: 1.) diisopropylamine, sec-Bu-Li, 2.) HMPA / 1.) THF, cyclohexane, 30 min, -78 deg C; 2.) THF, 2 h, -78 deg C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sec.-butyllithium; methanesulfonyl chloride; diisopropylamine;
In
methanol; triethylamine;
DOI:10.1021/jo00152a012
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / p-TsOH / 1 h / 25 °C
2: 50 percent / methanesulfonyl chloride / triethylamine / 18 h / 25 °C
3: 100 percent / KOH / methanol / 12 h / 25 °C
4: 1.) diisopropylamine, sec-Bu-Li, 2.) HMPA / 1.) THF, cyclohexane, 30 min, -78 deg C; 2.) THF, 2 h, -78 deg C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sec.-butyllithium; toluene-4-sulfonic acid; methanesulfonyl chloride; diisopropylamine;
In
methanol; triethylamine;
DOI:10.1021/jo00152a012
