(1S,5S,7aS)-5-[(1S)-1-[[(1,1-dimetylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]pentyl]-1-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-5,7a-dihydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one

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Chemical Name:(1S,5S,7aS)-5-[(1S)-1-[[(1,1-dimetylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]pentyl]-1-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-5,7a-dihydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one
CAS No.:698976-14-6
Molecular Formula:C₃₄H₅₉NO₆Si₂
Molecular Weight:634.017
Hs Code.:

(1S,5S,7aS)-5-[(1S)-1-[[(1,1-dimetylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]pentyl]-1-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-5,7a-dihydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one

Synonyms:(1S,5S,7aS)-5-[(1S)-1-[[(1,1-dimetylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]pentyl]-1-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-5,7a-dihydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one

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Chemical Property of (1S,5S,7aS)-5-[(1S)-1-[[(1,1-dimetylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]pentyl]-1-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-5,7a-dihydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one

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Technology Process of (1S,5S,7aS)-5-[(1S)-1-[[(1,1-dimetylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]pentyl]-1-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-5,7a-dihydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one

There total 6 articles about (1S,5S,7aS)-5-[(1S)-1-[[(1,1-dimetylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]pentyl]-1-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-5,7a-dihydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.6%

: 698976-09-9
3-{1-[1-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-pentyl]-allyl}-5-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-vinyl-oxazolidin-2-one

: 698976-14-6
(1S,5S,7aS)-5-[(1S)-1-[[(1,1-dimetylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]pentyl]-1-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-5,7a-dihydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one

Guidance literature:: Grubbs catalyst first generation; In dichloromethane; for 168h; Heating;
DOI:10.1055/s-2004-817773

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 698976-14-6
(1S,5S,7aS)-5-[(1S)-1-[[(1,1-dimetylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]pentyl]-1-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-5,7a-dihydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / imidazole / acetonitrile / 20 °C

2: LiOTf / acetonitrile / 96 h / 130 °C

3: 84 percent / Et₃N / CH₂Cl₂ / -40 °C

4: 92.6 percent / Grubbs' 1st generation catalyst / CH₂Cl₂ / 168 h / Heating

With 1H-imidazole; lithium trifluoromethanesulfonate; triethylamine; Grubbs catalyst first generation; In dichloromethane; acetonitrile;
DOI:10.1055/s-2004-817773

Reference yield:

: 2-[4-(4-methoxy-benzyloxy)-butyl]-3-vinyl-oxirane

: 698976-14-6
(1S,5S,7aS)-5-[(1S)-1-[[(1,1-dimetylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]pentyl]-1-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-5,7a-dihydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / aq. ammonia / 0.5 h / 110 °C / microwave irradiation

2: 85 percent / imidazole / acetonitrile / 20 °C

3: LiOTf / acetonitrile / 96 h / 130 °C

4: 84 percent / Et₃N / CH₂Cl₂ / -40 °C

5: 92.6 percent / Grubbs' 1st generation catalyst / CH₂Cl₂ / 168 h / Heating

With 1H-imidazole; ammonium hydroxide; lithium trifluoromethanesulfonate; triethylamine; Grubbs catalyst first generation; In dichloromethane; acetonitrile;
DOI:10.1055/s-2004-817773