exo-(1R,5S)-3-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2,6-difluorophenyl)-N-benzyloxy-3-azabicyclo[3.1.0]hexane-6-carboxamide

Base Information

Chemical Name:exo-(1R,5S)-3-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2,6-difluorophenyl)-N-benzyloxy-3-azabicyclo[3.1.0]hexane-6-carboxamide
CAS No.:681424-33-9
Molecular Formula:C₂₅H₂₆F₂N₄O₅
Molecular Weight:500.502
Hs Code.:

Synonyms:exo-(1R,5S)-3-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2,6-difluorophenyl)-N-benzyloxy-3-azabicyclo[3.1.0]hexane-6-carboxamide

Suppliers and Price of exo-(1R,5S)-3-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2,6-difluorophenyl)-N-benzyloxy-3-azabicyclo[3.1.0]hexane-6-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of exo-(1R,5S)-3-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2,6-difluorophenyl)-N-benzyloxy-3-azabicyclo[3.1.0]hexane-6-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of exo-(1R,5S)-3-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2,6-difluorophenyl)-N-benzyloxy-3-azabicyclo[3.1.0]hexane-6-carboxamide

There total 3 articles about exo-(1R,5S)-3-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2,6-difluorophenyl)-N-benzyloxy-3-azabicyclo[3.1.0]hexane-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 681424-92-0
(S)-(1α,5α,6α)-3-{4-[5-(acetylaminomethyl)-2-oxooxazolidin-3-yl]-2,6-difluorophenyl}-3-azabicyclo[3.1.0]hexane-6-carboxylic acid pentafluorophenyl ester

: 622-33-3
N-benzyloxyamine

: 681424-33-9
exo-(1R,5S)-3-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2,6-difluorophenyl)-N-benzyloxy-3-azabicyclo[3.1.0]hexane-6-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 2h;
DOI:10.1021/jm058204j

Reference yield:

: 681424-86-2
(S)-(1α,5α,6α)-3-{4-[5-(acetylaminomethyl)-2-oxooxazolidin-3-yl]-2,6-difluorophenyl}-3-azabicyclo[3.1.0]hexane-6-carboxylic acid tert-butyl ester

: 681424-33-9
exo-(1R,5S)-3-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2,6-difluorophenyl)-N-benzyloxy-3-azabicyclo[3.1.0]hexane-6-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / CH₂Cl₂ / 3 h

2: 0.031 g / pyridine / dimethylformamide / 2 h / 20 °C

3: 63 percent / diisopropylethylamine / dimethylformamide / 2 h

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm058204j

Reference yield:

: (S)-(1α,5α,6α)-3-{4-[5-(acetylaminomethyl)-2-oxooxazolidin-3-yl]-2,6-difluorophenyl}-3-azabicyclo[3.1.0]hexane-6-carboxylic acid trifluoroacetate

: 681424-33-9
exo-(1R,5S)-3-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2,6-difluorophenyl)-N-benzyloxy-3-azabicyclo[3.1.0]hexane-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 0.031 g / pyridine / dimethylformamide / 2 h / 20 °C

2: 63 percent / diisopropylethylamine / dimethylformamide / 2 h

With pyridine; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm058204j