N-{3-[5-(1-{1-[(1-Methyl-1H-pyrazol-4-yl)carbonyl]piperidin-4-yl}-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl]phenyl}-N'-(2,2,2-trifluoroethyl)urea

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Chemical Name:N-{3-[5-(1-{1-[(1-Methyl-1H-pyrazol-4-yl)carbonyl]piperidin-4-yl}-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl]phenyl}-N'-(2,2,2-trifluoroethyl)urea
CAS No.:1383480-15-6
Molecular Formula:C₂₉H₂₈F₃N₉O₂
Molecular Weight:591.596
Hs Code.:

Synonyms:N-{3-[5-(1-{1-[(1-Methyl-1H-pyrazol-4-yl)carbonyl]piperidin-4-yl}-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl]phenyl}-N'-(2,2,2-trifluoroethyl)urea

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Chemical Property of N-{3-[5-(1-{1-[(1-Methyl-1H-pyrazol-4-yl)carbonyl]piperidin-4-yl}-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl]phenyl}-N'-(2,2,2-trifluoroethyl)urea

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Technology Process of N-{3-[5-(1-{1-[(1-Methyl-1H-pyrazol-4-yl)carbonyl]piperidin-4-yl}-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl]phenyl}-N'-(2,2,2-trifluoroethyl)urea

There total 10 articles about N-{3-[5-(1-{1-[(1-Methyl-1H-pyrazol-4-yl)carbonyl]piperidin-4-yl}-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl]phenyl}-N'-(2,2,2-trifluoroethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-{3-[5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl]phenyl}-N'-(2,2,2-trifluoroethyl)urea hydrochloride

: 79583-19-0
1-methyl-1H-pyrazole-4-carbonyl chloride

: 1383480-15-6
N-{3-[5-(1-{1-[(1-Methyl-1H-pyrazol-4-yl)carbonyl]piperidin-4-yl}-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl]phenyl}-N'-(2,2,2-trifluoroethyl)urea

Guidance literature:: With pyridine; In acetonitrile; at 20 ℃;

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 1383480-15-6
N-{3-[5-(1-{1-[(1-Methyl-1H-pyrazol-4-yl)carbonyl]piperidin-4-yl}-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl]phenyl}-N'-(2,2,2-trifluoroethyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1-methyl-pyrrolidin-2-one / 150 °C

2.1: ethanol; tin(ll) chloride / 100 °C

3.1: hydrogenchloride / water / 150 °C

3.2: 2 h / 100 °C

4.1: dmap; triethylamine / tetrahydrofuran / 1 h / 20 °C

4.2: 20 °C

5.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 120 °C / Inert atmosphere

6.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 2 h / 20 °C

7.1: pyridine / acetonitrile / 20 °C

With pyridine; hydrogenchloride; dmap; ethanol; sodium carbonate; triethylamine; tin(ll) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; ethyl acetate; acetonitrile; 5.1: Suzuki Coupling;

Reference yield:

: 68621-88-5
(3-aminophenyl)carbamic acid tert-butyl ester

: 1383480-15-6
N-{3-[5-(1-{1-[(1-Methyl-1H-pyrazol-4-yl)carbonyl]piperidin-4-yl}-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl]phenyl}-N'-(2,2,2-trifluoroethyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1-methyl-pyrrolidin-2-one / 150 °C

2.1: ethanol; tin(ll) chloride / 100 °C

3.1: hydrogenchloride / water / 150 °C

3.2: 2 h / 100 °C

4.1: dmap; triethylamine / tetrahydrofuran / 1 h / 20 °C

4.2: 20 °C

5.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 120 °C / Inert atmosphere

6.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 2 h / 20 °C

7.1: pyridine / acetonitrile / 20 °C

With pyridine; hydrogenchloride; dmap; ethanol; sodium carbonate; triethylamine; tin(ll) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; ethyl acetate; acetonitrile; 5.1: Suzuki Coupling;