Technology Process of 4-[(5-bromo-2-chloro-phenyl)methyl]-2-fluoro-1-(1,1,2,2,2-pentadeuterioethoxy)benzene
There total 8 articles about 4-[(5-bromo-2-chloro-phenyl)methyl]-2-fluoro-1-(1,1,2,2,2-pentadeuterioethoxy)benzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-[(5-bromo-2-chloro-phenyl)methyl]-2-fluoro-phenol;
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
for 0.5h;
ethanol-d6;
In
tetrahydrofuran;
for 18h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.5 h / 20 °C
2.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 3 h
3.1: boron tribromide / dichloromethane / 4 h / Cooling with ice
4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h
4.2: 18 h
With
methanol; triethylsilane; sodium tetrahydroborate; di-isopropyl azodicarboxylate; boron trifluoride diethyl etherate; boron tribromide; triphenylphosphine;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 3 h
2.1: boron tribromide / dichloromethane / 4 h / Cooling with ice
3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h
3.2: 18 h
With
triethylsilane; di-isopropyl azodicarboxylate; boron trifluoride diethyl etherate; boron tribromide; triphenylphosphine;
In
tetrahydrofuran; dichloromethane;
