(2S,3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[3-fluoro-4-(1,1,2,2,2-pentadeuterioethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-carbaldehyde

Base Information

Chemical Name:(2S,3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[3-fluoro-4-(1,1,2,2,2-pentadeuterioethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-carbaldehyde
CAS No.:1358581-62-0
Molecular Formula:C₄₃H₄₂ClFO₇
Molecular Weight:730.214
Hs Code.:

(2S,3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[3-fluoro-4-(1,1,2,2,2-pentadeuterioethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-carbaldehyde

Synonyms:(2S,3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[3-fluoro-4-(1,1,2,2,2-pentadeuterioethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-carbaldehyde

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Chemical Property of (2S,3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[3-fluoro-4-(1,1,2,2,2-pentadeuterioethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-carbaldehyde

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Technology Process of (2S,3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[3-fluoro-4-(1,1,2,2,2-pentadeuterioethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-carbaldehyde

There total 13 articles about (2S,3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[3-fluoro-4-(1,1,2,2,2-pentadeuterioethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1358581-59-5
[(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[3-fluoro-4-(1,1,2,2,2-pentadeuterioethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-yl]methanol

: 1358581-62-0
(2S,3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[3-fluoro-4-(1,1,2,2,2-pentadeuterioethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-carbaldehyde

Guidance literature:: [(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[3-fluoro-4-(1,1,2,2,2-pentadeuterioethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-yl]methanol; With oxalyl dichloride; In dichloromethane; dimethyl sulfoxide; for 0.75h;

With triethylamine; In dichloromethane; dimethyl sulfoxide; at 20 ℃; for 2.5h;

Reference yield:

: 367-12-4
2-fluorophenol

: 1358581-62-0
(2S,3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[3-fluoro-4-(1,1,2,2,2-pentadeuterioethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-carbaldehyde

Guidance literature:: Multi-step reaction with 11 steps

1.1: potassium carbonate / acetone / 5 h / Reflux

2.1: aluminum (III) chloride / dichloromethane / 16 h / 0 °C

3.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.5 h / 20 °C

4.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 3 h

5.1: boron tribromide / dichloromethane / 4 h / Cooling with ice

6.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h

6.2: 18 h

7.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C

7.2: 3 h / -78 °C

7.3: 16 h / 20 °C

8.1: pyridine; dmap / 24 h

9.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

9.2: 3 h

10.1: acetyl chloride; methanol / 4 h

11.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.75 h

11.2: 2.5 h / 20 °C

With pyridine; methanol; triethylsilane; dmap; aluminum (III) chloride; sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; di-isopropyl azodicarboxylate; boron trifluoride diethyl etherate; boron tribromide; sodium hydride; potassium carbonate; acetyl chloride; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

: 451-80-9
1-ethoxy-2-fluoro-benzene

: 1358581-62-0
(2S,3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[3-fluoro-4-(1,1,2,2,2-pentadeuterioethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-carbaldehyde

Guidance literature:: Multi-step reaction with 10 steps

1.1: aluminum (III) chloride / dichloromethane / 16 h / 0 °C

2.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.5 h / 20 °C

3.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 3 h

4.1: boron tribromide / dichloromethane / 4 h / Cooling with ice

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h

5.2: 18 h

6.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C

6.2: 3 h / -78 °C

6.3: 16 h / 20 °C

7.1: pyridine; dmap / 24 h

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

8.2: 3 h

9.1: acetyl chloride; methanol / 4 h

10.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.75 h

10.2: 2.5 h / 20 °C

With pyridine; methanol; triethylsilane; dmap; aluminum (III) chloride; sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; di-isopropyl azodicarboxylate; boron trifluoride diethyl etherate; boron tribromide; sodium hydride; acetyl chloride; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;