1-(4-fluorophenyl)pyrido[2′,1′:2,3]imidazo[4,5-c][1,2,3]triazolo-[1,5-a]quinoline

Base Information

Chemical Name:1-(4-fluorophenyl)pyrido[2′,1′:2,3]imidazo[4,5-c][1,2,3]triazolo-[1,5-a]quinoline
CAS No.:1450724-98-7
Molecular Formula:C₂₁H₁₂FN₅
Molecular Weight:353.358
Hs Code.:

Synonyms:1-(4-fluorophenyl)pyrido[2′,1′:2,3]imidazo[4,5-c][1,2,3]triazolo-[1,5-a]quinoline

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Chemical Property of 1-(4-fluorophenyl)pyrido[2′,1′:2,3]imidazo[4,5-c][1,2,3]triazolo-[1,5-a]quinoline

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Technology Process of 1-(4-fluorophenyl)pyrido[2′,1′:2,3]imidazo[4,5-c][1,2,3]triazolo-[1,5-a]quinoline

There total 6 articles about 1-(4-fluorophenyl)pyrido[2′,1′:2,3]imidazo[4,5-c][1,2,3]triazolo-[1,5-a]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 766-98-3
1-ethynyl-4-fluorobenzene

: 115769-03-4
2-(2-bromophenyl)imidazo[1,2-α]pyridine

: 1450724-98-7
1-(4-fluorophenyl)pyrido[2′,1′:2,3]imidazo[4,5-c][1,2,3]triazolo-[1,5-a]quinoline

Guidance literature:: 1-ethynyl-4-fluorobenzene; 2-(2-bromophenyl)imidazo[1,2-α]pyridine; With copper(l) iodide; sodium azide; potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 6h;

With copper diacetate; palladium diacetate; acetic acid; In N,N-dimethyl-formamide; at 120 ℃; for 7h;

Reference yield: 62.0%

: 766-98-3
1-ethynyl-4-fluorobenzene

: 1450725-08-2
3-bromo-2-(2-bromophenyl)imidazo[1,2-a]pyridine

: 1450724-98-7
1-(4-fluorophenyl)pyrido[2′,1′:2,3]imidazo[4,5-c][1,2,3]triazolo-[1,5-a]quinoline

Guidance literature:: With sodium azide; copper(II) choride dihydrate; potassium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 24h;
DOI:10.1021/ol401655r

Reference yield:

: 49851-55-0
2,2'-dibromoacetophenone

: 1450724-98-7
1-(4-fluorophenyl)pyrido[2′,1′:2,3]imidazo[4,5-c][1,2,3]triazolo-[1,5-a]quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / ethanol / 2 h / Reflux

2: N-Bromosuccinimide / acetonitrile / 1 h / 25 °C

3: sodium azide; copper(II) choride dihydrate; potassium carbonate / N,N-dimethyl-formamide / 24 h / 150 °C

With N-Bromosuccinimide; sodium azide; copper(II) choride dihydrate; sodium hydrogencarbonate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol401655r