tert-butyl 2-[(3S)-4-(2-[(benzyloxycarbonyl)amino]acetyl)-3-[[(tert-butoxycarbonyl)amino]ethyl]-2-oxopiperazinyl]acetate

Base Information

Chemical Name:tert-butyl 2-[(3S)-4-(2-[(benzyloxycarbonyl)amino]acetyl)-3-[[(tert-butoxycarbonyl)amino]ethyl]-2-oxopiperazinyl]acetate
CAS No.:184576-25-8
Molecular Formula:C₂₇H₄₀N₄O₈
Molecular Weight:548.637
Hs Code.:

Synonyms:tert-butyl 2-[(3S)-4-(2-[(benzyloxycarbonyl)amino]acetyl)-3-[[(tert-butoxycarbonyl)amino]ethyl]-2-oxopiperazinyl]acetate

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Chemical Property of tert-butyl 2-[(3S)-4-(2-[(benzyloxycarbonyl)amino]acetyl)-3-[[(tert-butoxycarbonyl)amino]ethyl]-2-oxopiperazinyl]acetate

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Technology Process of tert-butyl 2-[(3S)-4-(2-[(benzyloxycarbonyl)amino]acetyl)-3-[[(tert-butoxycarbonyl)amino]ethyl]-2-oxopiperazinyl]acetate

There total 5 articles about tert-butyl 2-[(3S)-4-(2-[(benzyloxycarbonyl)amino]acetyl)-3-[[(tert-butoxycarbonyl)amino]ethyl]-2-oxopiperazinyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 184576-23-6
tert-butyl 2-[(3S)-3-[2-[(tert-butoxycarbonyl)amino]ethyl]-2-oxopiperazinyl]acetate

: 184576-25-8
tert-butyl 2-[(3S)-4-(2-[(benzyloxycarbonyl)amino]acetyl)-3-[[(tert-butoxycarbonyl)amino]ethyl]-2-oxopiperazinyl]acetate

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm0004345

Reference yield:

: 49855-91-6
2--4--L-2,4-diaminobutyric acid

: 184576-25-8
tert-butyl 2-[(3S)-4-(2-[(benzyloxycarbonyl)amino]acetyl)-3-[[(tert-butoxycarbonyl)amino]ethyl]-2-oxopiperazinyl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1: EDC / CH₂Cl₂ / 2 h / 20 °C

2: p-toluenesulfonic acid monohydrate / toluene / 4 h / 75 °C

3: H₂ / 10percent Pd/C / ethyl acetate / 2 h

4: 95 percent / EDC / CH₂Cl₂ / 1 h / 20 °C

With hydrogen; toluene-4-sulfonic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 10percent Pd/C; In dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jm0004345

Reference yield:

: 2-(2-tert-butoxycarbonylamino-ethyl)-4-tert-butoxycarbonylmethyl-3-oxo-3,4-dihydro-2H-pyrazine-1-carboxylic acid benzyl ester

: 184576-25-8
tert-butyl 2-[(3S)-4-(2-[(benzyloxycarbonyl)amino]acetyl)-3-[[(tert-butoxycarbonyl)amino]ethyl]-2-oxopiperazinyl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / ethyl acetate / 2 h

2: 95 percent / EDC / CH₂Cl₂ / 1 h / 20 °C

With hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 10percent Pd/C; In dichloromethane; ethyl acetate;
DOI:10.1021/jm0004345