Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala

Base Information

• Chemical Name: Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala
• CAS No.: 478363-03-0
• Molecular Formula: C₅₆H₉₂N₈O₁₅
• Molecular Weight: 1117.39
• Mol file: 478363-03-0.mol

Synonyms:Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala

Chemical Property of Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala

There total 3 articles about Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala-OBn (478363-01-8) → Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala (478363-03-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In dichloromethane; for 2h; under 760.051 Torr;

DOI:10.1021/np020117w

Reference yield:

C52H80N6O12 (187807-02-9) → Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala (478363-03-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pd/C / CH₂Cl₂ / 2 h / 760.05 Torr

2: 79 percent / i-Pr₂NEt; O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium BF₄ / dimethylformamide / 20 h

3: 99 percent / H₂ / Pd/C / CH₂Cl₂ / 2 h / 760.05 Torr

With hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/np020117w

Reference yield:

C45H74N6O12 (478362-98-0) → Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala (478363-03-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / i-Pr₂NEt; O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium BF₄ / dimethylformamide / 20 h

2: 99 percent / H₂ / Pd/C / CH₂Cl₂ / 2 h / 760.05 Torr

With hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/np020117w

upstream raw materials:

Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala-OBn

C₅₂H₈₀N₆O₁₂

C₄₅H₇₄N₆O₁₂

Downstream raw materials:

lyngbyastatin 1

Ibu-epilyngbyastatin 1