Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala-OBn

Base Information

• Chemical Name: Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala-OBn
• CAS No.: 478363-01-8
• Molecular Formula: C₆₃H₉₈N₈O₁₅
• Molecular Weight: 1207.52
• Mol file: 478363-01-8.mol

Synonyms:Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala-OBn

Chemical Property of Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala-OBn

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala-OBn

There total 2 articles about Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(S)-2-[((S)-4-Amino-2,2-dimethyl-3-oxo-pentanoyl)-methyl-amino]-propionic acid benzyl ester; compound with trifluoro-acetic acid + C45H74N6O12 (478362-98-0) → Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala-OBn (478363-01-8)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 20h;

DOI:10.1021/np020117w

Reference yield:

C52H80N6O12 (187807-02-9) → Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala-OBn (478363-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd/C / CH₂Cl₂ / 2 h / 760.05 Torr

2: 79 percent / i-Pr₂NEt; O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium BF₄ / dimethylformamide / 20 h

With hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/np020117w

Reference yield: 99.0%

Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala-OBn (478363-01-8) → Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala (478363-03-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In dichloromethane; for 2h; under 760.051 Torr;

DOI:10.1021/np020117w

upstream raw materials:

C₄₅H₇₄N₆O₁₂

C₅₂H₈₀N₆O₁₂

Downstream raw materials:

Boc-Map-Hmp-Gly-N-Me-L-Leu-Gly-N-Me-L-Val-O,N-diMe-L-Tyr-Ibu-N-Me-L-Ala

Ibu-epilyngbyastatin 1

lyngbyastatin 1