C₄₇H₅₄F₃NO₈

Base Information

• Chemical Name: C₄₇H₅₄F₃NO₈
• CAS No.: 1276112-40-3
• Molecular Formula: C₄₇H₅₄F₃NO₈
• Molecular Weight: 817.943
• Mol file: 1276112-40-3.mol

Synonyms:C₄₇H₅₄F₃NO₈

Chemical Property of C₄₇H₅₄F₃NO₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₇H₅₄F₃NO₈

There total 20 articles about C₄₇H₅₄F₃NO₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

C37H47NO6 (1276112-38-9) + (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) → C47H54F3NO8 (1276112-40-3)

Guidance literature:

With pyridine; at 20 ℃; for 120h;

DOI:10.1016/j.tetlet.2011.01.018

Reference yield:

C27H27NO5 (1308271-84-2) → C47H54F3NO8 (1276112-40-3)

Guidance literature:

Multi-step reaction with 15 steps

1: sodium tetrahydroborate / methanol / 24 h / 0 - 20 °C

2: silver(l) oxide / N,N-dimethyl-formamide / 24 h / 20 °C

3: ammonium cerium (IV) nitrate / water; acetonitrile / 2.5 h / 0 - 20 °C

4: dmap; triethylamine / dichloromethane / 2 h / 0 °C

5: tetrahydrofuran / 1.5 h / -78 °C

6: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 2 h / 0 °C

7: pyridine / 12 h / 0 - 20 °C

8: tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium formate; triethylamine / toluene / 0.5 h / Reflux

9: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone; tert-butyl alcohol / 24 h / 20 °C

10: sodium periodate / tetrahydrofuran; water / 3.5 h / 0 - 20 °C

11: t-butyldimethylsiyl triflate / toluene / 9 h / -78 °C

12: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone; tert-butyl alcohol / 24 h / 20 °C

13: sodium periodate / tetrahydrofuran; water / 4 h / 0 - 20 °C

14: magnesium / tetrahydrofuran / 3 h / -40 - -30 °C

15: pyridine / 120 h / 20 °C

With pyridine; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium cerium (IV) nitrate; cerium(III) chloride heptahydrate; t-butyldimethylsiyl triflate; ammonium formate; magnesium; 4-methylmorpholine N-oxide; triethylamine; silver(l) oxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; tert-butyl alcohol;

DOI:10.1016/j.tetlet.2011.01.018

Reference yield:

C27H29NO5 (1308271-86-4) → C47H54F3NO8 (1276112-40-3)

Guidance literature:

Multi-step reaction with 14 steps

1: silver(l) oxide / N,N-dimethyl-formamide / 24 h / 20 °C

2: ammonium cerium (IV) nitrate / water; acetonitrile / 2.5 h / 0 - 20 °C

3: dmap; triethylamine / dichloromethane / 2 h / 0 °C

4: tetrahydrofuran / 1.5 h / -78 °C

5: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 2 h / 0 °C

6: pyridine / 12 h / 0 - 20 °C

7: tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium formate; triethylamine / toluene / 0.5 h / Reflux

8: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone; tert-butyl alcohol / 24 h / 20 °C

9: sodium periodate / tetrahydrofuran; water / 3.5 h / 0 - 20 °C

10: t-butyldimethylsiyl triflate / toluene / 9 h / -78 °C

11: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone; tert-butyl alcohol / 24 h / 20 °C

12: sodium periodate / tetrahydrofuran; water / 4 h / 0 - 20 °C

13: magnesium / tetrahydrofuran / 3 h / -40 - -30 °C

14: pyridine / 120 h / 20 °C

With pyridine; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium cerium (IV) nitrate; cerium(III) chloride heptahydrate; t-butyldimethylsiyl triflate; ammonium formate; magnesium; 4-methylmorpholine N-oxide; triethylamine; silver(l) oxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; tert-butyl alcohol;

DOI:10.1016/j.tetlet.2011.01.018

upstream raw materials:

C₂₇H₂₇NO₅

C₂₇H₂₉NO₅

C₃₄H₃₅NO₅

C₂₆H₂₇NO₄