methyl {N'-[2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetyl]hydrazino}-2-oxo-acetate

Base Information

Chemical Name:methyl {N'-[2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetyl]hydrazino}-2-oxo-acetate
CAS No.:1289564-54-0
Molecular Formula:C₂₇H₃₆N₂O₆Si
Molecular Weight:512.678
Hs Code.:

Synonyms:methyl {N'-[2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetyl]hydrazino}-2-oxo-acetate

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Chemical Property of methyl {N'-[2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetyl]hydrazino}-2-oxo-acetate

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Technology Process of methyl {N'-[2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetyl]hydrazino}-2-oxo-acetate

There total 12 articles about methyl {N'-[2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetyl]hydrazino}-2-oxo-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1289564-46-0
2-hydroxy-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetonitrile

: 1289564-54-0
methyl {N'-[2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetyl]hydrazino}-2-oxo-acetate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / ethyl acetate / 16 h / Reflux; Inert atmosphere

2: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

3: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

With 1H-imidazole; hydrogenchloride; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm101597x

Reference yield:

: 1289564-48-2
methyl 2-hydroxy-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

: 1289564-54-0
methyl {N'-[2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetyl]hydrazino}-2-oxo-acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

2: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

With 1H-imidazole; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm101597x

Reference yield:

: 1289564-50-6
methyl 2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

: 1289564-54-0
methyl {N'-[2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetyl]hydrazino}-2-oxo-acetate

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

With water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm101597x