methyl 2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

Base Information

Chemical Name:methyl 2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetate
CAS No.:1289564-50-6
Molecular Formula:C₂₅H₃₄O₄Si
Molecular Weight:426.628
Hs Code.:

Synonyms:methyl 2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

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Technology Process of methyl 2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

There total 11 articles about methyl 2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1289564-48-2
methyl 2-hydroxy-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1289564-50-6
methyl 2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm101597x

Reference yield:

: 1289564-46-0
2-hydroxy-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetonitrile

: 1289564-50-6
methyl 2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate / 16 h / Reflux; Inert atmosphere

2: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

With 1H-imidazole; hydrogenchloride; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm101597x

Reference yield:

: 1289562-99-7
6-phenoxy-1,2,3,4-tetrahydronaphthalene-2-carboxaldehyde

: 1289564-50-6
methyl 2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; water / 16 h / 20 °C

2: hydrogenchloride / ethyl acetate / 16 h / Reflux; Inert atmosphere

3: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

With 1H-imidazole; hydrogenchloride; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm101597x