N-(2-bromophenyl)-4-(((2-iodophenyl)amino)methyl)-2,5-dimethoxyaniline

Base Information

Chemical Name:N-(2-bromophenyl)-4-(((2-iodophenyl)amino)methyl)-2,5-dimethoxyaniline
CAS No.:1620580-00-8
Molecular Formula:C₂₁H₂₀BrIN₂O₂
Molecular Weight:539.21
Hs Code.:

Synonyms:N-(2-bromophenyl)-4-(((2-iodophenyl)amino)methyl)-2,5-dimethoxyaniline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-bromophenyl)-4-(((2-iodophenyl)amino)methyl)-2,5-dimethoxyaniline

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Technology Process of N-(2-bromophenyl)-4-(((2-iodophenyl)amino)methyl)-2,5-dimethoxyaniline

There total 3 articles about N-(2-bromophenyl)-4-(((2-iodophenyl)amino)methyl)-2,5-dimethoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 615-43-0
2-iodophenylamine

: 1620579-95-4
4-((2-bromophenyl)amino)-2,5-dimethoxybenzaldehyde

: 1620580-00-8
N-(2-bromophenyl)-4-(((2-iodophenyl)amino)methyl)-2,5-dimethoxyaniline

Guidance literature:: With sodium tris(acetoxy)borohydride; trifluoroacetic acid; In Isopropyl acetate; at 20 ℃; for 0.2h; Inert atmosphere;
DOI:10.1039/c4ob00493k

Reference yield:

: 90064-47-4
4-iodo-2,5-dimethoxybenzenecarbaldehyde

: 1620580-00-8
N-(2-bromophenyl)-4-(((2-iodophenyl)amino)methyl)-2,5-dimethoxyaniline

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / acetonitrile / 12 h / 70 °C / Inert atmosphere

2: trifluoroacetic acid; sodium tris(acetoxy)borohydride / Isopropyl acetate / 0.2 h / 20 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium tris(acetoxy)borohydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; In Isopropyl acetate; acetonitrile; 1: |Buchwald-Hartwig Coupling;
DOI:10.1039/c4ob00493k

Reference yield:

: 93-02-7
2,5-dimethoxybenzaldehyde

: 1620580-00-8
N-(2-bromophenyl)-4-(((2-iodophenyl)amino)methyl)-2,5-dimethoxyaniline

Guidance literature:: Multi-step reaction with 3 steps

1: silver nitrate; iodine / methanol / 12 h / 20 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / acetonitrile / 12 h / 70 °C / Inert atmosphere

3: trifluoroacetic acid; sodium tris(acetoxy)borohydride / Isopropyl acetate / 0.2 h / 20 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iodine; sodium tris(acetoxy)borohydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; silver nitrate; trifluoroacetic acid; In methanol; Isopropyl acetate; acetonitrile; 2: |Buchwald-Hartwig Coupling;
DOI:10.1039/c4ob00493k