N-(4-((2-bromophenyl)amino)-2,5-dimethoxybenzyl)-N-(2-iodophenyl)acetamide

Base Information

Chemical Name:N-(4-((2-bromophenyl)amino)-2,5-dimethoxybenzyl)-N-(2-iodophenyl)acetamide
CAS No.:1620580-01-9
Molecular Formula:C₂₃H₂₂BrIN₂O₃
Molecular Weight:581.248
Hs Code.:

Synonyms:N-(4-((2-bromophenyl)amino)-2,5-dimethoxybenzyl)-N-(2-iodophenyl)acetamide

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Chemical Property of N-(4-((2-bromophenyl)amino)-2,5-dimethoxybenzyl)-N-(2-iodophenyl)acetamide

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Technology Process of N-(4-((2-bromophenyl)amino)-2,5-dimethoxybenzyl)-N-(2-iodophenyl)acetamide

There total 4 articles about N-(4-((2-bromophenyl)amino)-2,5-dimethoxybenzyl)-N-(2-iodophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1620580-00-8
N-(2-bromophenyl)-4-(((2-iodophenyl)amino)methyl)-2,5-dimethoxyaniline

: 75-36-5
acetyl chloride

: 1620580-01-9
N-(4-((2-bromophenyl)amino)-2,5-dimethoxybenzyl)-N-(2-iodophenyl)acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 5 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c4ob00493k

Reference yield:

: 90064-47-4
4-iodo-2,5-dimethoxybenzenecarbaldehyde

: 1620580-01-9
N-(4-((2-bromophenyl)amino)-2,5-dimethoxybenzyl)-N-(2-iodophenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / acetonitrile / 12 h / 70 °C / Inert atmosphere

2: trifluoroacetic acid; sodium tris(acetoxy)borohydride / Isopropyl acetate / 0.2 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 2 h / 5 - 20 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium tris(acetoxy)borohydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; trifluoroacetic acid; In dichloromethane; Isopropyl acetate; acetonitrile; 1: |Buchwald-Hartwig Coupling;
DOI:10.1039/c4ob00493k

Reference yield:

: 93-02-7
2,5-dimethoxybenzaldehyde

: 1620580-01-9
N-(4-((2-bromophenyl)amino)-2,5-dimethoxybenzyl)-N-(2-iodophenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: silver nitrate; iodine / methanol / 12 h / 20 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / acetonitrile / 12 h / 70 °C / Inert atmosphere

3: trifluoroacetic acid; sodium tris(acetoxy)borohydride / Isopropyl acetate / 0.2 h / 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 2 h / 5 - 20 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iodine; sodium tris(acetoxy)borohydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; silver nitrate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; Isopropyl acetate; acetonitrile; 2: |Buchwald-Hartwig Coupling;
DOI:10.1039/c4ob00493k