1,1-dimethylethyl (1S)-N-[1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-hydroxy]ethylcarbamate

Base Information

Chemical Name:1,1-dimethylethyl (1S)-N-[1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-hydroxy]ethylcarbamate
CAS No.:452305-62-3
Molecular Formula:C₂₂H₂₅BrN₂O₅S
Molecular Weight:509.421
Hs Code.:

Synonyms:1,1-dimethylethyl (1S)-N-[1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-hydroxy]ethylcarbamate

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Chemical Property of 1,1-dimethylethyl (1S)-N-[1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-hydroxy]ethylcarbamate

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Technology Process of 1,1-dimethylethyl (1S)-N-[1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-hydroxy]ethylcarbamate

There total 1 articles about 1,1-dimethylethyl (1S)-N-[1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-hydroxy]ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4248-19-5
tert-butyl carbazate

: 354538-27-5
6-bromo-1-tosyl-3-vinyl-1H-indole

: 1,1-dimethylethyl (1R)-N-[1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-hydroxy]ethylcarbamate

: 404888-90-0
1,1-dimethylethyl (1R)-N-[2-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-hydroxy]ethylcarbamate

: 452305-62-3
1,1-dimethylethyl (1S)-N-[1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-hydroxy]ethylcarbamate

: 1,1-dimethylethyl (1S)-N-[2-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-hydroxy]ethylcarbamate

Guidance literature:: With sodium hydroxide; Hydroquinone 1,4-phthalazinediyl diether; tert-butylhypochlorite; potassium dioxotetrahydroxoosmate(VI); In propan-1-ol; water; for 3h; Title compound not separated from byproducts;
DOI:10.1016/S0957-4166(02)00111-8

Reference yield: 86.0%

: 98-59-9
p-toluenesulfonyl chloride

: 452305-62-3
1,1-dimethylethyl (1S)-N-[1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-hydroxy]ethylcarbamate

: 452305-66-7
1,1-dimethylethyl (1S)-N-[1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-[(4-methylphenyl)sulfonyl]oxy]ethylcarbamate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1016/S0957-4166(02)00111-8

Reference yield:

: 452305-62-3
1,1-dimethylethyl (1S)-N-[1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-hydroxy]ethylcarbamate

: 452305-67-8
1,1-dimethylethyl (1S)-N-[1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-azido]ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / 4-dimethylaminopyridine; triethylamine / CH₂Cl₂ / 5 h / 20 °C

2: 88 percent / sodium azide / dimethylformamide / 12 h / 80 °C

With dmap; sodium azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(02)00111-8