N-{3-[4-(4-aminobenzyl)-1-piperidinyl]propyl}-N-(3,4-dichlorophenyl)-1-(methylsulfonyl)-4-piperidinecarboxamide

Base Information

Chemical Name:N-{3-[4-(4-aminobenzyl)-1-piperidinyl]propyl}-N-(3,4-dichlorophenyl)-1-(methylsulfonyl)-4-piperidinecarboxamide
CAS No.:333993-36-5
Molecular Formula:C₂₈H₃₈Cl₂N₄O₃S
Molecular Weight:581.607
Hs Code.:

Synonyms:N-{3-[4-(4-aminobenzyl)-1-piperidinyl]propyl}-N-(3,4-dichlorophenyl)-1-(methylsulfonyl)-4-piperidinecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{3-[4-(4-aminobenzyl)-1-piperidinyl]propyl}-N-(3,4-dichlorophenyl)-1-(methylsulfonyl)-4-piperidinecarboxamide

Chemical Property:

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Technology Process of N-{3-[4-(4-aminobenzyl)-1-piperidinyl]propyl}-N-(3,4-dichlorophenyl)-1-(methylsulfonyl)-4-piperidinecarboxamide

There total 11 articles about N-{3-[4-(4-aminobenzyl)-1-piperidinyl]propyl}-N-(3,4-dichlorophenyl)-1-(methylsulfonyl)-4-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 333993-35-4
N-(3,4-dichlorophenyl)-1-(methylsulfonyl)-N-{3-[4-(4-nitrobenzyl)-1-piperidinyl]propyl}-4-piperidinecarboxamide

: 333993-36-5
N-{3-[4-(4-aminobenzyl)-1-piperidinyl]propyl}-N-(3,4-dichlorophenyl)-1-(methylsulfonyl)-4-piperidinecarboxamide

Guidance literature:: With tin(ll) chloride; In ethanol; for 0.5h; Heating;
DOI:10.1016/j.bmc.2004.10.013

Reference yield:

: 333993-35-4
N-(3,4-dichlorophenyl)-1-(methylsulfonyl)-N-{3-[4-(4-nitrobenzyl)-1-piperidinyl]propyl}-4-piperidinecarboxamide

: 333993-36-5
N-{3-[4-(4-aminobenzyl)-1-piperidinyl]propyl}-N-(3,4-dichlorophenyl)-1-(methylsulfonyl)-4-piperidinecarboxamide

: 333993-28-5
1-acetyl-N-{3-[4-(4-aminobenzyl)-1-piperidinyl]propyl}-N-(3,4-dichlorophenyl)-4-piperidinecarboxamide

Guidance literature:

Reference yield:

: 241138-40-9
1-(methylsulfonyl)piperidine-4-carbonyl chloride

: 333993-36-5
N-{3-[4-(4-aminobenzyl)-1-piperidinyl]propyl}-N-(3,4-dichlorophenyl)-1-(methylsulfonyl)-4-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

2: 47 percent / KI; K₂CO₃ / acetonitrile / Heating

3: 89 percent / SnCl₂*2H₂O / ethanol / 0.5 h / Heating

With potassium carbonate; triethylamine; potassium iodide; tin(ll) chloride; In ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2004.10.013