1-(Methylsulfonyl)-4-piperidinecarbonyl chloride

Base Information

Chemical Name:1-(Methylsulfonyl)-4-piperidinecarbonyl chloride
CAS No.:241138-40-9
Molecular Formula:C7H12ClNO3S
Molecular Weight:225.696
Hs Code.:2935009090
European Community (EC) Number:889-396-1
DSSTox Substance ID:DTXSID70477826
Wikidata:Q82310755
Mol file:241138-40-9.mol

Synonyms:241138-40-9;1-(Methylsulfonyl)-4-piperidinecarbonyl chloride;1-(methylsulfonyl)piperidine-4-carbonyl chloride;1-methanesulfonylpiperidine-4-carbonyl chloride;1-methylsulfonylpiperidine-4-carbonyl chloride;SCHEMBL4682503;DTXSID70477826;NUDMYXJXBUZNNO-UHFFFAOYSA-N;MFCD09865018;AKOS005073320;LB-0726;1-(methylsulfonyl)piperidine-4-carbonylchloride;EN300-238615;J-503581;F2190-0152

Suppliers and Price of 1-(Methylsulfonyl)-4-piperidinecarbonyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
1-(Methylsulfonyl)piperidine-4-carbonyl chloride
1 g
$ 256.00

Matrix Scientific
1-(Methylsulfonyl)-4-piperidinecarbonyl chloride >95%
1g
$ 240.00

Matrix Scientific
1-(Methylsulfonyl)-4-piperidinecarbonyl chloride >95%
500mg
$ 200.00

Matrix Scientific
1-(Methylsulfonyl)-4-piperidinecarbonyl chloride >95%
5g
$ 905.00

American Custom Chemicals Corporation
1-(METHYLSULPHONYL)PIPERIDINE-4-CARBONYL CHLORIDE 95.00%
1G
$ 773.97

Total 2 raw suppliers

Chemical Property of 1-(Methylsulfonyl)-4-piperidinecarbonyl chloride

Chemical Property:

Melting Point:81～83℃
PSA：62.83000
LogP:1.44210
XLogP3:0.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:225.0226421
Heavy Atom Count:13
Complexity:287

Purity/Quality:

98%min ^*data from raw suppliers

1-(Methylsulfonyl)piperidine-4-carbonyl chloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CS(=O)(=O)N1CCC(CC1)C(=O)Cl

Technology Process of 1-(Methylsulfonyl)-4-piperidinecarbonyl chloride

There total 5 articles about 1-(Methylsulfonyl)-4-piperidinecarbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 280772-00-1
1-(Methylsulfonyl)-4-piperidine Carboxylic Acid

: 241138-40-9
1-(methylsulfonyl)piperidine-4-carbonyl chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2004.10.013

Reference yield:

: 280772-00-1
1-(Methylsulfonyl)-4-piperidine Carboxylic Acid

: 79-37-8
oxalyl dichloride

: 241138-40-9
1-(methylsulfonyl)piperidine-4-carbonyl chloride

Guidance literature:: In dichloromethane; N,N-dimethyl-formamide; Petroleum ether;

Reference yield:

: 498-94-2
isonipecotic acid

: 241138-40-9
1-(methylsulfonyl)piperidine-4-carbonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water / 3 h / 0 - 20 °C / Inert atmosphere

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.75 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane; water;
DOI:10.1021/acsmedchemlett.9b00445