6-((R,E)-3-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-hydroxyprop-1-enyl)-2,2-dimethyl-4H-1,3-dioxin-4-one

Base Information

Chemical Name:6-((R,E)-3-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-hydroxyprop-1-enyl)-2,2-dimethyl-4H-1,3-dioxin-4-one
CAS No.:1108203-30-0
Molecular Formula:C₂₃H₄₀O₅Si
Molecular Weight:424.653
Hs Code.:

Synonyms:6-((R,E)-3-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-hydroxyprop-1-enyl)-2,2-dimethyl-4H-1,3-dioxin-4-one

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Chemical Property of 6-((R,E)-3-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-hydroxyprop-1-enyl)-2,2-dimethyl-4H-1,3-dioxin-4-one

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Technology Process of 6-((R,E)-3-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-hydroxyprop-1-enyl)-2,2-dimethyl-4H-1,3-dioxin-4-one

There total 1 articles about 6-((R,E)-3-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-hydroxyprop-1-enyl)-2,2-dimethyl-4H-1,3-dioxin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₃₂O₃Si

: 126491-93-8
2,2-(dimethyl)-6-[(triphenylphosphoranylidene)methyl]-4H-1,3-dioxin-4-one

: 6-((S,E)-3-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-hydroxyprop-1-enyl)-2,2-dimethyl-4H-1,3-dioxin-4-one

: 1108203-30-0
6-((R,E)-3-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-hydroxyprop-1-enyl)-2,2-dimethyl-4H-1,3-dioxin-4-one

Guidance literature:: In dichloromethane; acetonitrile; at 20 ℃; diastereoselective reaction;
DOI:10.1021/ol802768p

Reference yield: 92.0%

: 1108203-30-0
6-((R,E)-3-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-hydroxyprop-1-enyl)-2,2-dimethyl-4H-1,3-dioxin-4-one

: 1108203-46-8
6-((R,E)-3-hydroxy-3-((1R,2R,4R)-2-(hydroxymethyl)-4-methylcyclohexyl)prop-1-enyl)-2,2-dimethyl-4H-1,3-dioxin-4-one

Guidance literature:: With acetic acid; In tetrahydrofuran; water; at 37 ℃;
DOI:10.1021/ol802768p

Reference yield: 66.0%

: 1108203-30-0
6-((R,E)-3-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-hydroxyprop-1-enyl)-2,2-dimethyl-4H-1,3-dioxin-4-one

: 79-22-1
methyl chloroformate

: 1108203-32-2
(R,E)-1-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)allyl methyl carbonate

Guidance literature:: 6-((R,E)-3-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-hydroxyprop-1-enyl)-2,2-dimethyl-4H-1,3-dioxin-4-one; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

methyl chloroformate; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol802768p