(R,E)-1-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)allyl methyl carbonate

Base Information

• Chemical Name: (R,E)-1-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)allyl methyl carbonate
• CAS No.: 1108203-32-2
• Molecular Formula: C₂₅H₄₂O₇Si
• Molecular Weight: 482.69

Synonyms:(R,E)-1-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)allyl methyl carbonate

Chemical Property of (R,E)-1-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)allyl methyl carbonate

Chemical Property:

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Technology Process of (R,E)-1-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)allyl methyl carbonate

There total 1 articles about (R,E)-1-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)allyl methyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

6-((R,E)-3-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-hydroxyprop-1-enyl)-2,2-dimethyl-4H-1,3-dioxin-4-one (1108203-30-0) + methyl chloroformate (79-22-1) → (R,E)-1-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)allyl methyl carbonate (1108203-32-2)

Guidance literature:

6-((R,E)-3-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-hydroxyprop-1-enyl)-2,2-dimethyl-4H-1,3-dioxin-4-one; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

methyl chloroformate; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol802768p

Reference yield: 80.0%

(R,E)-1-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)allyl methyl carbonate (1108203-32-2) → (R,E)-3-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-1-((1R,2R,4R)-2-(hydroxymethyl)-4-methylcyclohexyl)allyl methyl carbonate (1108203-47-9)

Guidance literature:

With acetic acid; In tetrahydrofuran; water; at 37 ℃;

DOI:10.1021/ol802768p

upstream raw materials:

6-((R,E)-3-((1R,2R,4R)-2-((tert-butyldimethylsilyloxy)methyl)-4-methylcyclohexyl)-3-hydroxyprop-1-enyl)-2,2-dimethyl-4H-1,3-dioxin-4-one

methyl chloroformate

Downstream raw materials:

(R,E)-3-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-1-((1R,2R,4R)-2-(hydroxymethyl)-4-methylcyclohexyl)allyl methyl carbonate

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