1-(phenylsulfonyl)-2-(1-azidoethyl)-3-indolyl methyl ketone

Base Information

• Chemical Name: 1-(phenylsulfonyl)-2-(1-azidoethyl)-3-indolyl methyl ketone
• CAS No.: 146253-25-0
• Molecular Formula: C₁₈H₁₆N₄O₃S
• Molecular Weight: 368.416
• Mol file: 146253-25-0.mol

Synonyms:1-(phenylsulfonyl)-2-(1-azidoethyl)-3-indolyl methyl ketone

Chemical Property of 1-(phenylsulfonyl)-2-(1-azidoethyl)-3-indolyl methyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(phenylsulfonyl)-2-(1-azidoethyl)-3-indolyl methyl ketone

There total 4 articles about 1-(phenylsulfonyl)-2-(1-azidoethyl)-3-indolyl methyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(phenylsulfonyl)-2-(1-bromoethyl)-3-indolyl methyl ketone (146253-24-9) → 1-(phenylsulfonyl)-2-(1-azidoethyl)-3-indolyl methyl ketone (146253-25-0)

Guidance literature:

With sodium azide; In tetrahydrofuran; water; for 4h; Ambient temperature;

DOI:10.1016/S0040-4020(01)88360-5

Reference yield:

1-(2-ethyl-1H-indol-3-yl)-ethan-1-one (17422-23-0) → 1-(phenylsulfonyl)-2-(1-azidoethyl)-3-indolyl methyl ketone (146253-25-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) KH, 2) imidazole / 1) dimethoxyethane, room temperature, 1 h, 2) dimethoxyethane, room temperature, 15 h

2: 90 percent / NBS, dibenzoyl peroxide / CCl₄ / 4 h / Heating

3: 95 percent / NaN₃ / tetrahydrofuran; H₂O / 4 h / Ambient temperature

With 1H-imidazole; N-Bromosuccinimide; sodium azide; potassium hydride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; water;

DOI:10.1016/S0040-4020(01)88360-5

Reference yield:

1-(phenylsulfonyl)-2-ethyl-3-indolyl methyl ketone (146253-23-8) → 1-(phenylsulfonyl)-2-(1-azidoethyl)-3-indolyl methyl ketone (146253-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / NBS, dibenzoyl peroxide / CCl₄ / 4 h / Heating

2: 95 percent / NaN₃ / tetrahydrofuran; H₂O / 4 h / Ambient temperature

With N-Bromosuccinimide; sodium azide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; water;

DOI:10.1016/S0040-4020(01)88360-5

upstream raw materials:

1-(phenylsulfonyl)-2-(1-bromoethyl)-3-indolyl methyl ketone

1-(2-ethyl-1H-indol-3-yl)-ethan-1-one

1-(phenylsulfonyl)-2-ethyl-3-indolyl methyl ketone

benzenesulfonyl chloride

Downstream raw materials:

4-(phenylsulfonyl)-2-(tert-butoxycarbonyl)-1,3-dimethyl-2,4-dihydropyrrolo<3,4-b>indole

4-(phenylsulfonyl)-1,3-dimethyl-2,4-dihydropyrrolo<3,4-b>indole