Technology Process of 1-(phenylsulfonyl)-2-ethyl-3-indolyl methyl ketone
There total 5 articles about 1-(phenylsulfonyl)-2-ethyl-3-indolyl methyl ketone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
acetic anhydride;
With
aluminum (III) chloride;
In
dichloromethane;
at -0.16 ℃;
for 0.333333h;
2-ethyl-1-(phenylsulfonyl)-1H-indole;
In
dichloromethane;
at -0.16 ℃;
for 2.5h;
With
water;
DOI:10.1007/s10870-009-9603-3
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane / 0 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: sec.-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 °C / Inert atmosphere
3.2: 2.5 h / 0 °C / Inert atmosphere
With
aluminum (III) chloride; sec.-butyllithium; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.3390/molecules25020261
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sec.-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 °C / Inert atmosphere
2.2: 2.5 h / 0 °C / Inert atmosphere
With
aluminum (III) chloride; sec.-butyllithium;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.3390/molecules25020261
