tert-butyl N-[5-bromo-3-[5-[4-(bromomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyrazin-2-yl]-N-tert-butoxycarbonylcarbamate

Base Information

• Chemical Name: tert-butyl N-[5-bromo-3-[5-[4-(bromomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyrazin-2-yl]-N-tert-butoxycarbonylcarbamate
• CAS No.: 1225062-88-3
• Molecular Formula: C₂₃H₂₅Br₂N₅O₅
• Molecular Weight: 611.29
• Mol file: 1225062-88-3.mol

Synonyms:tert-butyl N-[5-bromo-3-[5-[4-(bromomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyrazin-2-yl]-N-tert-butoxycarbonylcarbamate

Chemical Property of tert-butyl N-[5-bromo-3-[5-[4-(bromomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyrazin-2-yl]-N-tert-butoxycarbonylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl N-[5-bromo-3-[5-[4-(bromomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyrazin-2-yl]-N-tert-butoxycarbonylcarbamate

There total 3 articles about tert-butyl N-[5-bromo-3-[5-[4-(bromomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyrazin-2-yl]-N-tert-butoxycarbonylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

di-tert-butyl dicarbonate (24424-99-5) + 5-bromo-3-[5-[4-(bromomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyrazin-2-amine (1225062-87-2) → tert-butyl N-[5-bromo-3-[5-[4-(bromomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyrazin-2-yl]-N-tert-butoxycarbonylcarbamate (1225062-88-3)

Guidance literature:

With dmap; In tetrahydrofuran; at 50 ℃; for 3h;

Reference yield:

methyl 3-amino-6-bromopyrazine-2-carboxylate (6966-01-4) → tert-butyl N-[5-bromo-3-[5-[4-(bromomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyrazin-2-yl]-N-tert-butoxycarbonylcarbamate (1225062-88-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrazine hydrate / ethanol / 1.5 h / 70 °C

2.1: dibromotriphenylphosphorane / acetonitrile / 1 h / 20 °C / Inert atmosphere

2.2: 20 - 30 °C

3.1: dmap / tetrahydrofuran / 3 h / 50 °C

With dmap; hydrazine hydrate; dibromotriphenylphosphorane; In tetrahydrofuran; ethanol; acetonitrile;

Reference yield:

3-amino-6-bromopyrazine-2-carbohydrazide (1225062-23-6) → tert-butyl N-[5-bromo-3-[5-[4-(bromomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyrazin-2-yl]-N-tert-butoxycarbonylcarbamate (1225062-88-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dibromotriphenylphosphorane / acetonitrile / 1 h / 20 °C / Inert atmosphere

1.2: 20 - 30 °C

2.1: dmap / tetrahydrofuran / 3 h / 50 °C

With dmap; dibromotriphenylphosphorane; In tetrahydrofuran; acetonitrile;

upstream raw materials:

di-tert-butyl dicarbonate

5-bromo-3-[5-[4-(bromomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyrazin-2-amine

methyl 3-amino-6-bromopyrazine-2-carboxylate

3-amino-6-bromopyrazine-2-carbohydrazide