(2R,5S)-5-benzyl-3-(4-methylphenyl)-2-phenyltetrahydro-4H-imidazol-4-one

Base Information

Chemical Name:(2R,5S)-5-benzyl-3-(4-methylphenyl)-2-phenyltetrahydro-4H-imidazol-4-one
CAS No.:479191-75-8
Molecular Formula:C₂₃H₂₂N₂O
Molecular Weight:342.44
Hs Code.:

Synonyms:(2R,5S)-5-benzyl-3-(4-methylphenyl)-2-phenyltetrahydro-4H-imidazol-4-one

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Chemical Property of (2R,5S)-5-benzyl-3-(4-methylphenyl)-2-phenyltetrahydro-4H-imidazol-4-one

Chemical Property:

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Technology Process of (2R,5S)-5-benzyl-3-(4-methylphenyl)-2-phenyltetrahydro-4H-imidazol-4-one

There total 4 articles about (2R,5S)-5-benzyl-3-(4-methylphenyl)-2-phenyltetrahydro-4H-imidazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 100-52-7
benzaldehyde

: 21171-98-2
(2S)-2-amino-N-(4-methylphenyl)-3-phenylpropanamide

: 479191-76-9
(2S,5S)-5-benzyl-3-(4-methylphenyl)-2-phenyltetrahydro-4H-imidazol-4-one

: 479191-75-8
(2R,5S)-5-benzyl-3-(4-methylphenyl)-2-phenyltetrahydro-4H-imidazol-4-one

Guidance literature:: With toluene-4-sulfonic acid; sodium sulfate; In dichloromethane; for 12h; Heating;
DOI:10.1021/jo0203241

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 479191-75-8
(2R,5S)-5-benzyl-3-(4-methylphenyl)-2-phenyltetrahydro-4H-imidazol-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: ClCOOBu-i; N-methylmorpholine

2: CF₃CO₂H / CH₂Cl₂

3: 38 percent / p-TsOH; Na₂SO₄ / CH₂Cl₂ / 12 h / Heating

With 4-methyl-morpholine; toluene-4-sulfonic acid; sodium sulfate; trifluoroacetic acid; isobutyl chloroformate; In dichloromethane;
DOI:10.1021/jo0203241

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 479191-75-8
(2R,5S)-5-benzyl-3-(4-methylphenyl)-2-phenyltetrahydro-4H-imidazol-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: ClCOOBu-i; N-methylmorpholine

2: CF₃CO₂H / CH₂Cl₂

3: 38 percent / p-TsOH; Na₂SO₄ / CH₂Cl₂ / 12 h / Heating

With 4-methyl-morpholine; toluene-4-sulfonic acid; sodium sulfate; trifluoroacetic acid; isobutyl chloroformate; In dichloromethane;
DOI:10.1021/jo0203241